BACKGROUNDNo gold standard exists in the world of scientific image acquisition; a proliferation of instruments each with its own proprietary data format has made out-of-the-box sharing of that data nearly impossible. In the field of light microscopy, the Bio-Formats library was designed to translate such proprietary data formats to a common, open-source schema, enabling sharing and reproduction of scientific results. While Bio-Formats has proved successful for microscopy images, the greater scientific community was lacking a domain-independent framework for format translation.
RESULTSSCIFIO (SCientific Image Format Input and Output) is presented as a freely available, open-source library unifying the mechanisms of reading and writing image data. The core of SCIFIO is its modular definition of formats, the design of which clearly outlines the components of image I/O to encourage extensibility, facilitated by the dynamic discovery of the SciJava plugin framework. SCIFIO is structured to support coexistence of multiple domain-specific open exchange formats, such as Bio-Formats’ OME-TIFF, within a unified environment.
CONCLUSIONSSCIFIO is a freely available software library developed to standardize the process of reading and writing scientific image formats.
SCIFIO: an extensible framework to support scientific image formats.
Description: LY2979165 is a novel potent agent that is used as Anti-depressants. LY2979165 is under clinical study. A Safety Study of LY2979165 is performing in Healthy Subjects. LY2979165 is useful for Anti-depressants.
Description: LY2979165 is a novel potent agent that is used as Anti-depressants. LY2979165 is under clinical study. A Safety Study of LY2979165 is performing in Healthy Subjects. LY2979165 is useful for Anti-depressants.
Description: Wnt agonist 1 is a small-molecule agonist of Wnt signaling pathway. The Wnt signaling pathway is an important signal transduction pathway that involved in a variety of physiological and pathological processes by regulating genes involved in cellular adhesion, proliferation, and differentiation.
Description: Wnt agonist 1 is a small-molecule agonist of Wnt signaling pathway. The Wnt signaling pathway is an important signal transduction pathway that involved in a variety of physiological and pathological processes by regulating genes involved in cellular adhesion, proliferation, and differentiation.
Description: Wnt agonist 1 is a small-molecule agonist of Wnt signaling pathway. The Wnt signaling pathway is an important signal transduction pathway that involved in a variety of physiological and pathological processes by regulating genes involved in cellular adhesion, proliferation, and differentiation.
Description: Wnt agonist 1 is a small-molecule agonist of Wnt signaling pathway. The Wnt signaling pathway is an important signal transduction pathway that involved in a variety of physiological and pathological processes by regulating genes involved in cellular adhesion, proliferation, and differentiation.
Description: Anti-CD20 is a recombinant monoclonal antibody which features the constant region of the human IgG1 isotype and the variable region of rituximab. It binds to human CD20 extracellular region a.a 142- 184, where it acts asan agonist of the CD20 protein. Itis expressed in a 293 freestyle cell expression system and purified using protein A chromatography. MW = 150 kDa.
Description: The substance Troglitazone is a ppargamma agonist. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO and to 10 mM in ethanol.
Description: The substance Troglitazone is a ppargamma agonist. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO and to 10 mM in ethanol.
Description: The substance Kainic acid is a kainate agonist. It is synthetically produced and has a purity of >99%. The pure substance is white powder which is May be dissolved in water (10 mg/ml).
Description: The substance Kainic acid is a kainate agonist. It is synthetically produced and has a purity of >99%. The pure substance is white powder which is May be dissolved in water (10 mg/ml).
Description: Anti-CD27 agonist antibody binds to CD27 on T cells and promotes T cell response. It represents new opportunities for cancer immunotherapy.
Description: Anti-CD27 agonist antibody binds to CD27 on T cells and promotes T cell response. It represents new opportunities for cancer immunotherapy.
Description: Recombinant monoclonal antibody recognizing human CD28. This antibody binds to CD28 on T cells and promotes T cell response. Not tested in other species. This antibody crosslinked with FcGR2B is useful for activation of CD27 costimulatory pathway in T cells.
Description: Recombinant monoclonal antibody recognizing human CD28. This antibody binds to CD28 on T cells and promotes T cell response. Not tested in other species.
Description: Anti-CD137 recombinant human antibody recognizing the CD137 ligand binding region. This antibody not been tested for cross-reactivity with other species.
Description: Anti-CD137 recombinant human antibody recognizing the CD137 ligand binding region. This antibody not been tested for cross-reactivity with other species.
Description: The substance VU0467154 is a m4 receptor agonist. It is synthetically produced and has a purity of >98%. The pure substance is tan solid which is soluble in DMSO.
Description: The substance Bexarotene is a retinoid rxr agonist. It is synthetically produced and has a purity of >98%. The pure substance is white powder which is soluble in DMSO (60 mg/ml) or ethanol (warm, 10 mg/ml).
Description: The substance Bexarotene is a retinoid rxr agonist. It is synthetically produced and has a purity of >98%. The pure substance is white powder which is soluble in DMSO (60 mg/ml) or ethanol (warm, 10 mg/ml).
Description: The substance WY-14643 is a ppar alpha agonist. It is synthetically produced and has a purity of 0.985. The pure substance is off white powder which is soluble in DMSO (40 mg/ml).
Description: The substance WY-14643 is a ppar alpha agonist. It is synthetically produced and has a purity of 0.985. The pure substance is off white powder which is soluble in DMSO (40 mg/ml).
Description: The FXR (Farnesoid X Receptor) Agonist Assay Kit (TR-FRET) is designed to measure binding of the FXR and SRC-1 (Steroid Receptor Coactivator 1) for screening FXR agonists using TR-FRET technology. With this homogeneous kit, the FXR agonist assay can be performed by adding all materials, including the detection reagents, to the wells and incubating the plate for 2-hours at room temperature followed by reading the TR-FRET signal._x000D_
Description: The substance Retinoic acid is a retinoid rar agonist. It is synthetically produced and has a purity of >98%. The pure substance is yellow solid which is soluble to 50 mM in ethanol and 25 mM in DMSO.
Description: The substance Retinoic acid is a retinoid rar agonist. It is synthetically produced and has a purity of >98%. The pure substance is yellow solid which is soluble to 50 mM in ethanol and 25 mM in DMSO.
Description: Recombinant monoclonal antibody recognizing human CD28. This antibody binds to CD28 on T cells and promotes T cell response. Not tested in other species. This antibody crosslinked with FcGR2B is useful for activation of CD27 costimulatory pathway in T cells. This antibody has been humanized to reduce immunogenicity and improve the therapeutic half-life.
Description: Recombinant monoclonal antibody recognizing human CD28. This antibody binds to CD28 on T cells and promotes T cell response. Not tested in other species. This antibody has been humanized to reduce immunogenicity and improve the therapeutic half-life.
Description: The substance BzATP is a prototypic p2x7 receptor agonist. It is synthetically produced and has a purity of >97.7%. The pure substance is off white solid which is soluble in water..
Description: The substance BzATP is a prototypic p2x7 receptor agonist. It is synthetically produced and has a purity of >97.7%. The pure substance is off white solid which is soluble in water..
Description: The substance Quisqualic Acid is a glutamate receptor agonist. It is isolated from quisqualis fructus and has a purity of 0.999. The pure substance is off white solid which is soluble to 100 mM in 1eq. NaOH; 10 mM in water.
Description: The substance Quisqualic Acid is a glutamate receptor agonist. It is isolated from quisqualis fructus and has a purity of 0.999. The pure substance is off white solid which is soluble to 100 mM in 1eq. NaOH; 10 mM in water.
Description: Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring inflammatory inhibitor protein. It inhibits the activity of IL-1α and IL-1β by competitively blocking binding to their type I and type II receptors. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL-1Ra may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease. Recombinant human IL-1Ra is a 17.2 kDa protein consisting of 153 amino acid residues.
Description: Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring inflammatory inhibitor protein. It inhibits the activity of IL-1α and IL-1β by competitively blocking binding to their type I and type II receptors. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL-1Ra may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease. Recombinant human IL-1Ra is a 17.2 kDa protein consisting of 153 amino acid residues.
Description: Ki: 8.5 nM4-Quinolone-3-Carboxamide Furan CB2 Agonist is a high-affinity ligand of CB2.The endocannabinoid system consists of endogenous cannabinoids (endocannabinoids), cannabinoid receptors (primarily CB1 and CB2), and the enzymes that synthesize and degrade endocannabinoids.
Description: Ki: 8.5 nM4-Quinolone-3-Carboxamide Furan CB2 Agonist is a high-affinity ligand of CB2.The endocannabinoid system consists of endogenous cannabinoids (endocannabinoids), cannabinoid receptors (primarily CB1 and CB2), and the enzymes that synthesize and degrade endocannabinoids.
Description: Ki: 8.5 nM4-Quinolone-3-Carboxamide Furan CB2 Agonist is a high-affinity ligand of CB2.The endocannabinoid system consists of endogenous cannabinoids (endocannabinoids), cannabinoid receptors (primarily CB1 and CB2), and the enzymes that synthesize and degrade endocannabinoids.
BH3-Interacting Domain Death Agonist (BID) Protein
Description: The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.
Bid Antibody / BH3-Interacting Domain Death Agonist
Description: The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.
Description: A competitive ELISA for quantitative measurement of Rat BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat BH3 Interacting Domain Death Agonist ELISA kit
Description: A competitive ELISA for quantitative measurement of Rat BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat BH3 Interacting Domain Death Agonist ELISA kit
Description: A competitive ELISA for quantitative measurement of Rat BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
BCL2 Associated Agonist of Cell Death (BAD) Antibody
Description: A competitive ELISA for quantitative measurement of Canine BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog BH3 Interacting Domain Death Agonist ELISA kit
Description: A competitive ELISA for quantitative measurement of Canine BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog BH3 Interacting Domain Death Agonist ELISA kit
Description: A competitive ELISA for quantitative measurement of Canine BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig BH3 Interacting Domain Death Agonist ELISA kit
Description: A competitive ELISA for quantitative measurement of Porcine BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig BH3 Interacting Domain Death Agonist ELISA kit
Description: A competitive ELISA for quantitative measurement of Porcine BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig BH3 Interacting Domain Death Agonist ELISA kit
Description: A competitive ELISA for quantitative measurement of Porcine BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
