SCIFIO: an extensible framework to support scientific image formats.

SCIFIO: an extensible framework to support scientific image formats.

BACKGROUNDNo gold standard exists in the world of scientific image acquisition; a proliferation of instruments each with its own proprietary data format has made out-of-the-box sharing of that data nearly impossible. In the field of light microscopy, the Bio-Formats library was designed to translate such proprietary data formats to a common, open-source schema, enabling sharing and reproduction of scientific results. While Bio-Formats has proved successful for microscopy images, the greater scientific community was lacking a domain-independent framework for format translation.

RESULTSSCIFIO (SCientific Image Format Input and Output) is presented as a freely available, open-source library unifying the mechanisms of reading and writing image data. The core of SCIFIO is its modular definition of formats, the design of which clearly outlines the components of image I/O to encourage extensibility, facilitated by the dynamic discovery of the SciJava plugin framework. SCIFIO is structured to support coexistence of multiple domain-specific open exchange formats, such as Bio-Formats’ OME-TIFF, within a unified environment.

CONCLUSIONSSCIFIO is a freely available software library developed to standardize the process of reading and writing scientific image formats.

 SCIFIO: an extensible framework to support scientific image formats.
SCIFIO: an extensible framework to support scientific image formats.

mGlu2 agonist

A3601-5 5 mg
EUR 382
Description: Anti-depressants,novel potent agent

mGlu2 agonist

A3601-5.1 10 mM (in 1mL H2O)
EUR 506.4
Description: LY2979165 is a novel potent agent that is used as Anti-depressants. LY2979165 is under clinical study. A Safety Study of LY2979165 is performing in Healthy Subjects. LY2979165 is useful for Anti-depressants.

mGlu2 agonist

A3601-50 50 mg
EUR 2050
Description: Anti-depressants,novel potent agent

PPARδ agonist

T12527-10mg 10mg Ask for price
Description: PPARδ agonist

PPARδ agonist

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Description: PPARδ agonist

PPARδ agonist

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Description: PPARδ agonist

PPARδ agonist

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Description: PPARδ agonist

PPARδ agonist

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Description: PPARδ agonist

STING agonist-10

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Description: STING agonist-10

STING agonist-10

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Description: STING agonist-10

STING agonist-10

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Description: STING agonist-10

STING agonist-10

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Description: STING agonist-10

STING agonist-10

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Description: STING agonist-10

STING agonist-11

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Description: STING agonist-11

STING agonist-11

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Description: STING agonist-11

STING agonist-11

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Description: STING agonist-11

STING agonist-11

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Description: STING agonist-11

STING agonist-11

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Description: STING agonist-11

STING agonist-16

HY-131994 1 mg
EUR 378.79
Description: STING agonist-16 (1a) is a specific stimulator of interferon genes (STING) agonist. STING agonist-16 (1a) can be used as a potential antiviral and antitumor tool[1].

STING agonist-18

HY-150074 Get quote Ask for price
Description: STING agonist-18 (compound 1a) can be used for synthesis of antibody-drug conjugates (ADCs), such Trastuzumab (HY-P9907) conjugate[1].

STING agonist-19

HY-150075 Get quote Ask for price
Description: STING agonist-19 can be used to synthesize ISAC (immune-stimulating antibody conjugates) molecule.

STING agonist-15

HY-122568 500 μg
EUR 168.83
Description: STING agonist-15 (Compound STING agonist-C11) Is a STING agonist. STING agonist-15 can be used for research of cancer and immune response[1].

STING agonist-14

HY-139179 Get quote Ask for price
Description: STING agonist-14 (compound 12b) is a potent STING agonist that is efficacious across species. STING agonist-14 could activate the pathway by directly binding human STING. STING agonist-14 can be used for the research of tumours or viral infections[1].

STING agonist-17

HY-143320 1 mg
EUR 3625.6
Description: STING agonist-17 (compound 4a) is a potent STING agonist with an IC50 value of 0.062 nM. STING agonist-17 has anti-cancer activity for tumor immunization[1].

STING agonist-13

HY-143321 Get quote Ask for price
Description: STING agonist-13 is a stimulator of interferon genes (STING) agonist, for cancer immunity via STING-mediated immune activation. STING agonist-13 can stimulate STING downstream signaling and promoting type I interferon immune responses. STING agonist-13 significantly decreases tumor volume and shows immunological memory-derived cancer inhibition[1].

STING agonist-10

HY-144328 Get quote Ask for price
Description: STING agonist-10 (Compound 91) is a potent small molecule cyclic urea activator of STING with the EC50 of 2600 nM. Activation of STING is a highly promising approach in immunotherapy[1].

STING agonist-11

HY-144329 Get quote Ask for price
Description: STING agonist-11 (Compound 92) is a potent small molecule cyclic urea activator of STING with EC50 of 18 nM. Activation of STING is a highly promising approach in immunotherapy[1].

STING agonist-12

HY-147010 10 mg
EUR 551.96
Description: STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM[1].

STING agonist-20

HY-148068 1 mg
EUR 5194.89
Description: STING agonist-20 (compound 95) is a potent STING agonist used in the synthesis of XMT-2056. STING agonist-20 can be used as a vaccine adjuvant in the study of cancer and other inflammatory, immune diseases[1].

STING agonist-21

HY-148546 Get quote Ask for price
Description: STING agonist-21 (compound 1) is a STING agonist, with an EC50 of 592.8 nM. STING agonist-21 can be used for cancer research[1].

STING agonist-30

HY-149267 Get quote Ask for price
Description: STING agonist-30 is a potent STING agonist. STING agonist-30 exhibits STING-dependent immune activation. STING agonist-30 has extensive inhibitory effects on various viruses, including the herpes simplex virus (HSV), rotavirus, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)[1].

STING agonist-34

HY-149781 Get quote Ask for price
Description: STING agonist-34 (Compound 12L) is a potent STING agonist with an IC50 value of 1.15 μM and an EC50 of 0.38 μM in THP1 cells. STING agonist-34 could be used in cancer research[1].

STING agonist-22

HY-152955 1 mg
EUR 5519.57
Description: STING agonist-22 (CF501) is a potent non-nucleotide STING agonist. STING agonist-22 is a adjuvant by activating STING to induce the type I interferon (IFN-I) response and proinflammatory cytokine production. STING agonist-22 can be used as an adjuvant to boost the original protein vaccine, producing potent, broad, and long-term immune protection. STING agonist-22 can be used for SARS-CoV-2 variants and sarbecovirus diseases research[1].

STING agonist-23

HY-152956 1 mg
EUR 811.7
Description: STING agonist-23 (CF502) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains[1].

STING agonist-24

HY-152957 Get quote Ask for price
Description: STING agonist-24 (CF504) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains[1].

STING agonist-25

HY-152958 Get quote Ask for price
Description: STING agonist-25 (CF505) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains[1].

STING agonist-26

HY-152959 1 mg
EUR 743.52
Description: STING agonist-26 (CF508) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains[1].

STING agonist-27

HY-152960 Get quote Ask for price
Description: STING agonist-27 (CF509) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, exhibits activity against SARS-CoV series strains[1].

STING agonist-28

HY-152961 Get quote Ask for price
Description: STING agonist-28 (CF510) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains[1].

STING agonist-29

HY-152962 Get quote Ask for price
Description: STING agonist-29 (CF511) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, exhibits activity against SARS-CoV series strains[1].

STING agonist-31

HY-153546 Get quote Ask for price
Description: STING agonist-31 is a STING agonist, with EC50 values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency[1].

STING agonist-33

HY-153987 Get quote Ask for price
Description: STING agonist-33 (example 1) is an agonist of STING (stimulator of interferon genes) based on 4-ethyl-2-methylthiazole-5-carboxylic acid[1].

ROR agonist-1

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Description: ROR agonist-1

ROR agonist-1

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Description: ROR agonist-1

ROR agonist-1

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Description: ROR agonist-1

ROR agonist-1

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Description: ROR agonist-1

ROR agonist-1

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Description: ROR agonist-1

CBR Agonist-1

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Description: CBR Agonist-1

CBR Agonist-1

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Description: CBR Agonist-1

CBR Agonist-1

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Description: CBR Agonist-1

CBR Agonist-1

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Description: CBR Agonist-1

CBR Agonist-1

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Description: CBR Agonist-1

CBR Agonist-2

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Description: CBR Agonist-2

CBR Agonist-2

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Description: CBR Agonist-2

CBR Agonist-2

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Description: CBR Agonist-2

CBR Agonist-2

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Description: CBR Agonist-2

CBR Agonist-2

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Description: CBR Agonist-2

ROR agonist-1

MBS3843033-10mg 10mg
EUR 1905

ROR agonist-1

MBS3843033-1mg 1mg
EUR 430

ROR agonist-1

MBS3843033-5mg 5mg
EUR 1165

ROR agonist-1

MBS3843033-5x10mg 5x10mg
EUR 8565

ROR agonist-1

MBS5767512-5mg 5mg
EUR 915

ROR agonist-1

MBS5767512-5x5mg 5x5mg
EUR 3970

MOR agonist-2

HY-155706 Get quote Ask for price
Description: MOR agonist-2 (compound 46) is a antagonist of D3R and agonist of MOR (Ki: 7.26 nM and 564 nM, respectively). MOR agonist-2 has the potential to produce analgesic effects through MOR partial agonism. MOR agonist-2 reduces opioid-misuse liability via D3R antagonism[1].

MOR agonist-3

HY-155707 Get quote Ask for price
Description: MOR agonist-3 (Compound 84) is a D3R/MOR antagonist (Ki 382 nM and 55.2 nM respectively). MOR agonist-3 has the potential to produce analgesic effects through MOR (μ-opioid receptor) (HY-149337) partial agonists and to reduce opioid abuse through D3R antagonists. MOR agonist-3 can be used in the treatment of inflammation and neuropathic pain research[1].

NOP agonist-1

HY-156972 Get quote Ask for price
Description: NOP agonist-1(compound 4) is a nociceptin opioid receptor (NOP) partial agonist. NOP agonist-1attenuate parkinsonian disabilities in 6-OHDA hemilesioned rats[1].

NOP agonist-2

HY-156993 Get quote Ask for price
Description: NOP agonist-2 is a selective NOP agonist[1].

CBR Agonist-1

HY-151105 Get quote Ask for price
Description: CBR Agonist-1 (27a-cis) is a cannabinoid receptor (CBR) agonist with the Ki values of 0.18 μM for CB1R and 1.22 μM for CB2R. CBR Agonist-1 (27a-cis) can be used in the study of endogenous cannabinoid system-related diseases[1].

CBR Agonist-2

HY-151107 Get quote Ask for price
Description: CBR Agonist-2 is a CB1 agonist (CB1R; CB1 ligand) with an EC50 and a Ki of 960 nM and 970 nM, respectively. CBR Agonist-2 is a promising tool for investigating the involvement of hCB1R in disorders associated with the endocannabinoid system[1].

ROR agonist-1

HY-128353 Get quote Ask for price
Description: ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor C2 (RORC2), inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5[1].

D4R agonist-1

HY-149481 Get quote Ask for price
Description: D4R agonist-1 (Compound 16f) is a D4R partial agonist (Ki: 2.2 nM). D4R agonist-1 is metabolically stable in rat and human liver microsomes. D4R agonist-1 can be used for research of neuropsychiatric disorders[1].

MOR agonist-1

HY-153471 Get quote Ask for price
Description: MOR agonist-1 is a MOR (μ-opioid receptor) agonist. MOR agonist-1 has good analgesic effect. MOR agonist-1 can be used for the research of pain and pain-related disorders[1].

A2AR agonist-1

574042 1.0mg
EUR 310

LXRβ agonist-2

T11899-10mg 10mg Ask for price
Description: LXRβ agonist-2

LXRβ agonist-2

T11899-1g 1g Ask for price
Description: LXRβ agonist-2

LXRβ agonist-2

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Description: LXRβ agonist-2

LXRβ agonist-2

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Description: LXRβ agonist-2

LXRβ agonist-2

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Description: LXRβ agonist-2

ERRγ agonist-1

T60772-10mg 10mg Ask for price
Description: ERRγ agonist-1

ERRγ agonist-1

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Description: ERRγ agonist-1

ERRγ agonist-1

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Description: ERRγ agonist-1

ERRγ agonist-1

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Description: ERRγ agonist-1

ERRγ agonist-1

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Description: ERRγ agonist-1

FFA1 agonist-1

T62856-10mg 10mg Ask for price
Description: FFA1 agonist-1

FFA1 agonist-1

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Description: FFA1 agonist-1

FFA1 agonist-1

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Description: FFA1 agonist-1

FFA1 agonist-1

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Description: FFA1 agonist-1

FFA1 agonist-1

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Description: FFA1 agonist-1

LXRβ agonist-3

T63989-10mg 10mg Ask for price
Description: LXRβ agonist-3

LXRβ agonist-3

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Description: LXRβ agonist-3

LXRβ agonist-3

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Description: LXRβ agonist-3

LXRβ agonist-3

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Description: LXRβ agonist-3

LXRβ agonist-3

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Description: LXRβ agonist-3

FAA1 agonist-1

MBS3841977-100mg 100mg
EUR 840

FAA1 agonist-1

MBS3841977-10mg 10mg
EUR 255

FAA1 agonist-1

MBS3841977-50mg 50mg
EUR 630

FAA1 agonist-1

MBS3841977-5mg 5mg
EUR 200

FAA1 agonist-1

MBS3841977-5x100mg 5x100mg
EUR 3765

LXRβ agonist-2

HY-100469 Get quote Ask for price
Description: LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM, displays 28.5-fold selectivity over LXRα (EC50=200 nM) and used in the treatment of atherosclerosis[1].

LXRβ agonist-4

HY-152262 Get quote Ask for price
Description: LXRβ agonist-4 is a potent, orally active Liver X receptors (LXRs) agonist with an IC50 value of 0.0078 μM for LXRβ. LXRβ agonist-4 inhibits RANKL-induced osteoclast differentiation and bone resorption. LXRβ agonist-4 can be used in research of osteoporosis[1].

MFN2 agonist-1

HY-123985 Get quote Ask for price
Description: MFN2 agonist-1 (B-A/l) potently stimulates mitochondrial fusion in mitofusin 2 (MFN2)-deficient cells. MFN2 agonist-1 reverses mitochondrial “clumping” (formation of static mitochondrial aggregates) and restores mitochondrial motility in cultured mouse neurons expressing the CMT2A mutant MFN2 T105M.

ERRγ agonist-1

HY-145848 10 mg
EUR 1374.48
Description: ERRγ agonist-1 is a potent ERRγ agonist. ERRγ agonist-1 increases transcriptional activities of ERRγ. ERRγ agonist-1 has the potential for the research of neuropsychological disorders[1].

LXRβ agonist-3

HY-146275 Get quote Ask for price
Description: LXRβ agonist-3 (compound 4-13) is a potent and selective LXRβ (liver X receptor β) agonist, with an EC50 of 0.095 μM. LXRβ agonist-3 efficiently inhibits U87EGFRvIII cell, with an IC50 of 3.75 μM. LXRβ agonist-3 shows antitumor activity, and can inhibit glioblastoma[1].

FFA1 agonist-1

HY-147987 Get quote Ask for price
Description: FFA1 agonist-1 (Compound 17a) is an orally active fatty acid receptor 1 (FFA1) agonist with an EC50 of 0.75 μM. FFA1 agonist-1 can be used for type 2 diabetes mellitus research[1].

TLR4 agonist-1

HY-149650 Get quote Ask for price
Description: TLR4 agonist-1 (compound 17a) is a potent agonist of Toll-like Receptor 4 (TLR4), and induces the generation of MIP-1β in RAW 264.7 and MM6 cells[1].

Aβ42 agonist-1

HY-149763 Get quote Ask for price
Description: Aβ42 agonist-1 (compound 7a) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-1 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-1 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells[1].

Aβ42 agonist-2

HY-149764 Get quote Ask for price
Description: Aβ42 agonist-2 (compound 7b) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-2 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-2 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells[1].

SOS1 agonist-1

HY-153606 10 mg
EUR 1136.38
Description: SOS1 agonist-1 (compound 79) is an agonist for the Son of sevenless homologue SOS1. SOS1 is a guanine nucleotide exchange factor that catalyzes the exchange of GDP to GTP on RAS and regulates RAS activation. SOS1 agonists increase nucleotide exchange on RAS, enhance cellular RAS-GTP levels, and trigger biphasic signaling changes in ERK1/2 phosphorylation. Play an anti-cancer role[1].

GPR3 agonist-2

HY-155318A Get quote Ask for price
Description: GPR3 agonist-2(compound 32) is a potent full agonist of G protein-coupled receptor 3, with the IC50of 260 nM[1].

GPCR agonist-2

HY-47823 10mg
EUR 37.88
Description: GPCR agonist-2 (Compound 5j) is a GPCR GPR109b (HM74) agonist, with a pEC50 value of 6.51. GPCR agonist-2 can be used for research of lipid disorders[1].

STING agonist-1

B7835-10 10 mg
EUR 554

STING agonist-1

B7835-100 100mg
EUR 2329

STING agonist-1

B7835-5 5mg
EUR 388

STING agonist-1

B7835-50 50 mg
EUR 1663

GPR30 agonist-1

T40517-10mg 10mg Ask for price
Description: GPR30 agonist-1

GPR30 agonist-1

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Description: GPR30 agonist-1

GPR30 agonist-1

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Description: GPR30 agonist-1

GPR30 agonist-1

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Description: GPR30 agonist-1

GPR30 agonist-1

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Description: GPR30 agonist-1

STING agonist-4

HY-123943 5mg
EUR 639.6

STING agonist-1

HY-19711 100mg
EUR 3531.6

STING agonist-3

HY-103665 5mg
EUR 542.4

TRPV4 agonist-1

T13214-10mg 10mg Ask for price
Description: TRPV4 agonist-1

TRPV4 agonist-1

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Description: TRPV4 agonist-1

TRPV4 agonist-1

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Description: TRPV4 agonist-1

TRPV4 agonist-1

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Description: TRPV4 agonist-1

TRPV4 agonist-1

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Description: TRPV4 agonist-1

STING agonist-3

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Description: STING agonist-3

STING agonist-3

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Description: STING agonist-3

STING agonist-3

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Description: STING agonist-3

STING agonist-3

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Description: STING agonist-3

STING agonist-3

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Description: STING agonist-3

STING agonist-4

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Description: STING agonist-4

STING agonist-4

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Description: STING agonist-4

STING agonist-4

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Description: STING agonist-4

STING agonist-4

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Description: STING agonist-4

STING agonist-4

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Description: STING agonist-4

GPR41 agonist-1

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Description: GPR41 agonist-1

GPR41 agonist-1

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Description: GPR41 agonist-1

GPR41 agonist-1

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Description: GPR41 agonist-1

GPR41 agonist-1

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Description: GPR41 agonist-1

GPR41 agonist-1

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Description: GPR41 agonist-1

TREM2 agonist-2

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Description: TREM2 agonist-2

TREM2 agonist-2

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Description: TREM2 agonist-2

TREM2 agonist-2

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Description: TREM2 agonist-2

TREM2 agonist-2

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Description: TREM2 agonist-2

TREM2 agonist-2

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Description: TREM2 agonist-2

GPR52 agonist-1

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Description: GPR52 agonist-1

GPR52 agonist-1

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Description: GPR52 agonist-1

GPR52 agonist-1

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Description: GPR52 agonist-1

GPR52 agonist-1

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Description: GPR52 agonist-1

GPR52 agonist-1

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Description: GPR52 agonist-1

TREM2 agonist-1

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Description: TREM2 agonist-1

TREM2 agonist-1

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Description: TREM2 agonist-1

TREM2 agonist-1

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Description: TREM2 agonist-1

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