Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial.

Left ventricular (LV) dysfunction c-kit-positive, lineage-negative cardiac stem cells (CSC) improving post-infarction when given to animals. We conducted an experiment phase 1 (Stem Cell Infusion in Patients with ischemic cardiomyopathy [Scipio]) from autologous CSC for the treatment of heart failure due to ischemic heart disease.In trial stage A Scipio, patients with post-infarction LV dysfunction (ejection fraction [EF] ≤ 40%) prior to coronary artery bypass grafting were consecutively enrolled in the treatment and control groups. In stage B, patients were randomly assigned to treatment or control groups in a ratio of 2: 3 by using the block scheme of computer-generated randomization. 1 million autologous CSC given by intracoronary infusion at an average of 113 days (SE 4) after surgery; untreated controls.

Although this study is an open label, echocardiographic analysis did not know the duties of the group. The primary endpoint was a short-term security of CSC and the secondary endpoint was efficacy. A per-protocol analysis were used. This study is registered with ClinicalTrials.gov, number NCT00474461.This study is still in progress. 16 patients were assigned to the treatment group and seven for the control group; no side effects were reported related CSC.

On 14 CSC-treated patients were analyzed, LVEF increased from 30 · 3% (SE 1 · 9) before CSC infusion to 38 · 5% (2 · 8) at 4 months after infusion (p = 0 · 001). In contrast, the seven control patients, as long as the appropriate time interval, LVEF did not change (30 · 1% [2 · 4] at 4 months after CABG vs 30 · 2% [2 · 5] at 8 months after CABG). Importantly, CSC healthful effects are even more pronounced in the first year in eight patients (eg, LVEF increased by 12 · 3 unit ejection fraction [2 · 1] vs baseline, p = 0 · 0007).

In seven patients treated in whom cardiac MRI can be done, infarct size decreased from 32 · 6 g (6 · 3) by 7 · 8 g (1 · 7; 24%) at 4 months (p = 0 · 004) and 9 · 8 g (3 · 5; 30%) at 1 year (p = 0 · 04) .This preliminary results in patients with very encouraging. They suggest that intracoronary infusion of autologous CSC effective in improving LV systolic function and reduced infarct size in patients with heart failure after myocardial infarction, and warrant further, larger, phase 2 studies.University of Louisville Research Foundation and the National Institutes of Health ,

D-Luciferin, Sodium Salt

7902-25G Ask for price

D-Luciferin, Sodium Salt

7902-3PK
EUR 925

D-Luciferin, Sodium Salt

7902-50G Ask for price

D-Luciferin, Sodium Salt

7902-5PK
EUR 1496

D-Luciferin, sodium salt

10102 10MG
EUR 123
Description: Minimum order quantity: 1 unit of 10MG

D-Luciferin, sodium salt

10102-1 50MG
EUR 245
Description: Minimum order quantity: 1 unit of 50MG

D-Luciferin, sodium salt

10102-2 1G
EUR 714
Description: Minimum order quantity: 1 unit of 1G

D-Luciferin (sodium salt)

HY-12591 50mg
EUR 153

D-Luciferin sodium salt

B8311-10 10 mg
EUR 131

D-Luciferin sodium salt

B8311-200 200 mg
EUR 699

D-Luciferin sodium salt

B8311-50 50 mg
EUR 293

D-Luciferin, Potassium Salt

7903-100
EUR 120

D-Luciferin, Potassium Salt

7903-10G
EUR 2409

D-Luciferin, Potassium Salt

7903-10PK
EUR 2763

D-Luciferin, Potassium Salt

7903-1G
EUR 354

D-Luciferin, Potassium Salt

7903-25G Ask for price

D-Luciferin, Potassium Salt

7903-3PK
EUR 925

D-Luciferin, Potassium Salt

7903-50G Ask for price

D-Luciferin, Potassium Salt

7903-5PK
EUR 1496

D-Luciferin, potassium salt

10101 10MG
EUR 112
Description: Minimum order quantity: 1 unit of 10MG

D-Luciferin, potassium salt

10101-1 50MG
EUR 234
Description: Minimum order quantity: 1 unit of 50MG

D-Luciferin, potassium salt

10101-2 1G
EUR 714
Description: Minimum order quantity: 1 unit of 1G

D-Luciferin, Potassium Salt

D0510-010 100mg
EUR 185

D-Luciferin, Potassium Salt

D0510-050 500mg
EUR 504

D-Luciferin, Potassium Salt

D0510-100 1g
EUR 847

D-Luciferin potassium salt

HY-12591B 50mg
EUR 153

D-Luciferin, sodium salt *CAS#: 103404-75-7*

12509 25 mg
EUR 115

D-Luciferin, sodium salt *CAS#: 103404-75-7*

12510 100 mg
EUR 132

D-Luciferin, sodium salt *CAS#: 103404-75-7*

12511 1 g
EUR 528

EZSolution? D-Luciferin, Potassium Salt

B3001-set
EUR 370

Brite-Light? D-Luciferin, Potassium Salt

B3000-10PK
EUR 2268

Brite-Light? D-Luciferin, Potassium Salt

B3000-1G
EUR 327

Brite-Light? D-Luciferin, Potassium Salt

B3000-5PK
EUR 1300

D-Luciferin

GP9319-100MG 100 mg
EUR 221

D-Luciferin

GP9319-10MG 10 mg
EUR 70

D-Luciferin

GP9319-25MG 25 mg
EUR 110

D-Luciferin

GP9319-50MG 50 mg
EUR 150

D-Luciferin

HY-12591A 10mg
EUR 108

D-Luciferin

B6040-10 10 mg
EUR 131
Description: D-luciferin is a cell-permeable chemiluminescent luciferase substrate with a Km of approximately 2 ?M. D-luciferin could emit lights upon oxidative decarboxylation in the presence of ATP.

D-Luciferin

B6040-200 200 mg
EUR 699
Description: D-luciferin is a cell-permeable chemiluminescent luciferase substrate with a Km of approximately 2 ?M. D-luciferin could emit lights upon oxidative decarboxylation in the presence of ATP.

D-Luciferin

B6040-50 50 mg
EUR 293
Description: D-luciferin is a cell-permeable chemiluminescent luciferase substrate with a Km of approximately 2 ?M. D-luciferin could emit lights upon oxidative decarboxylation in the presence of ATP.

D-Luciferin, potassium salt *CAS#: 115144-35-9*

12505 25 mg
EUR 115

D-Luciferin, potassium salt *CAS#: 115144-35-9*

12506 100 mg
EUR 132

D-Luciferin, potassium salt *CAS#: 115144-35-9*

12507 1 g
EUR 263

D-Luciferin acetate

12516 5 mg
EUR 219

Methyl beta-D-glucuronide sodium salt

GC4190-1G 1 g
EUR 229

Methyl beta-D-glucuronide sodium salt

GC4190-250MG 250 mg
EUR 110

D-Glucuronic acid sodium salt monohydrate

GC8431-100G 100 g
EUR 126

D-Glucuronic acid sodium salt monohydrate

GC8431-250G 250 g
EUR 229

D-Glucuronic acid sodium salt monohydrate

GC8431-25G 25 g
EUR 70

D-Glucuronic acid sodium salt monohydrate

GC8431-5G 5 g
EUR 46

D-Glucosamine 2-sulfate sodium salt

GC9126-25MG 25 mg
EUR 61

D-Glucuronic acid, sodium salt, monohydrate

GB0483 5g
EUR 107.42

Estradiol 17-(?-D-Glucuronide) (sodium salt)

C3840-5 5 mg
EUR 132
Description: Km: 75 ?MEstradiol 17-(?-D-Glucuronide) is a substrate of the multidrug resistance protein 2 (MRP2).MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes.

Estradiol 17-(?-D-Glucuronide) (sodium salt)

C3840-10 10 mg
EUR 206
Description: Km: 75 ?MEstradiol 17-(?-D-Glucuronide) is a substrate of the multidrug resistance protein 2 (MRP2).MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes.

Estradiol 17-(?-D-Glucuronide) (sodium salt)

C3840-25 25 mg
EUR 338
Description: Km: 75 ?MEstradiol 17-(?-D-Glucuronide) is a substrate of the multidrug resistance protein 2 (MRP2).MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes.

Estradiol 17-(?-D-Glucuronide) (sodium salt)

C3840-50 50 mg
EUR 502
Description: Km: 75 ?MEstradiol 17-(?-D-Glucuronide) is a substrate of the multidrug resistance protein 2 (MRP2).MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes.

Estradiol 3-(?-D-Glucuronide) (sodium salt)

C3897-1 1 mg
EUR 118
Description: ?-estradiol 3-(?-d-glucuronide) (E23G) is a noncholestatic regioisomer of the estrogen metabolite, E217G (?-Estradiol 17-(?-d-glucuronide)) [1]. E23G functions as a substrate for multidrug resistance associated protein 2 (MRP2) [2].

Estradiol 3-(?-D-Glucuronide) (sodium salt)

C3897-10 10 mg
EUR 527
Description: ?-estradiol 3-(?-d-glucuronide) (E23G) is a noncholestatic regioisomer of the estrogen metabolite, E217G (?-Estradiol 17-(?-d-glucuronide)) [1]. E23G functions as a substrate for multidrug resistance associated protein 2 (MRP2) [2].

Estradiol 3-(?-D-Glucuronide) (sodium salt)

C3897-25 25 mg
EUR 1073
Description: ?-estradiol 3-(?-d-glucuronide) (E23G) is a noncholestatic regioisomer of the estrogen metabolite, E217G (?-Estradiol 17-(?-d-glucuronide)) [1]. E23G functions as a substrate for multidrug resistance associated protein 2 (MRP2) [2].

Estradiol 3-(?-D-Glucuronide) (sodium salt)

C3897-5 5 mg
EUR 306
Description: ?-estradiol 3-(?-d-glucuronide) (E23G) is a noncholestatic regioisomer of the estrogen metabolite, E217G (?-Estradiol 17-(?-d-glucuronide)) [1]. E23G functions as a substrate for multidrug resistance associated protein 2 (MRP2) [2].

D-Luciferin (Free acid)

2779-1000
EUR 338

D-Luciferin (Free acid)

2779-250
EUR 175

D-Luciferin (Free acid)

2779-500
EUR 251

D-Luciferin (Free acid)

2779-5000
EUR 1273

D-Luciferin, free acid

10100 10MG
EUR 112
Description: Minimum order quantity: 1 unit of 10MG

D-Luciferin, free acid

10100-1 50MG
EUR 234
Description: Minimum order quantity: 1 unit of 50MG

D-Luciferin, free acid

10100-2 1G
EUR 714
Description: Minimum order quantity: 1 unit of 1G

DMNPE-Caged D-Luciferin: (5mg)

10103 5MG
EUR 148
Description: Minimum order quantity: 1 unit of 5MG

D-Luciferin-6-O-beta-D-galactopyranoside

B1802-25
EUR 892

D-Luciferin-6-O-beta-D-galactopyranoside

B1802-5
EUR 262

Hepes, Sodium Salt

CH039 25 g
EUR 118

Hepes, Sodium Salt

CH040 100 g
EUR 169

Hepes, Sodium Salt

CH041 500 g
EUR 374

Ampicillin Sodium Salt

AK0839-0010 10g Ask for price

Ampicillin Sodium Salt

AK0839-0025 25g Ask for price

Ampicillin Sodium Salt

AK0839-0100 100g Ask for price

Heparin Sodium Salt

AK3004-1000 1g Ask for price

Heparin Sodium Salt

AK3004-5000 5g Ask for price

Thyroxine (Sodium salt)

30-AT52 1 gram
EUR 352
Description: High purity Thyroxine sodium salt

Triiodothyronine (Sodium salt)

30-AT53 1 gram
EUR 849
Description: High purity (>99%) Triiodothyronine sodium salt

Nigericin sodium salt

2096-25
EUR 387

Nigericin sodium salt

2096-5
EUR 147

NADP, sodium salt

2737-100
EUR 153

NADP, sodium salt

2737-1000
EUR 784

NADP, sodium salt

2737-500
EUR 457

Novobiocin Sodium Salt

B1526-1G
EUR 109

Novobiocin Sodium Salt

B1526-5G
EUR 240

Cefazolin Sodium Salt

B1530-1G
EUR 142

Cefazolin Sodium Salt

B1530-5G
EUR 359

Cefoxitin Sodium Salt

B1892-1G
EUR 185

Cefoxitin Sodium Salt

B1892-500
EUR 131

Cefoxitin Sodium Salt

B1892-5G
EUR 577

Cefotaxime Sodium Salt

abx188641-100g 100 g
EUR 509

Tianeptine Sodium Salt

abx188914-25g 25 g
EUR 314

CAPS, sodium salt

CB0097 50g
EUR 71.75

CAPSO, sodium salt

CD0041 50g
EUR 76.1

Cefamandole sodium salt

C079-100MG 100 mg
EUR 148

Cefamandole sodium salt

C079-500MG 500 mg
EUR 474

Resazurin, sodium salt

10054 10MG
EUR 148
Description: Minimum order quantity: 1 unit of 10MG

Cefotaxime Sodium Salt

20-abx082178
  • EUR 217.00
  • EUR 175.00
  • 100 mg
  • 5 g

PIPES Sodium Salt

20-abx082438
  • EUR 272.00
  • EUR 189.00
  • 250 g
  • 25 g

Carboxymethylcellulose sodium salt

abx082467-100g 100 g
EUR 189

Ampicillin Sodium Salt

abx082587-5g 5 g
EUR 175

TAPS, sodium salt

TB0920 50g
EUR 71.75

TAPSO, sodium salt

TB0922 50g
EUR 102.2

MES sodium salt

GB1926-10G 10 g
EUR 50

MES sodium salt

GB1926-250G 250 g
EUR 181

MES sodium salt

GB1926-500G 500 g
EUR 298

MOPSO sodium salt

GB3228-100G 100 g
EUR 94

MOPSO sodium salt

GB3228-25G 25 g
EUR 58

MOPSO sodium salt

GB3228-500G 500 g
EUR 229

TES sodium salt

GB4016-100G 100 g
EUR 150

TES sodium salt

GB4016-500G 500 g
EUR 429

CAPSO sodium salt

GB4515-100G 100 g
EUR 110

CAPSO sodium salt

GB4515-25G 25 g
EUR 54

CAPSO sodium salt

GB4515-500G 500 g
EUR 309

MOPS sodium salt

GB8397-100G 100 g
EUR 66

MOPS sodium salt

GB8397-1KG 1 kg
EUR 257

DIPSO sodium salt

GB8985-250G 250 g
EUR 628

BES sodium salt

GB9133-25G 25 g
EUR 86

HEPES sodium salt

GB9181-250G 250 g
EUR 99

HEPES sodium salt

GB9181-500G 500 g
EUR 150

Heparin sodium salt

GC2310-100MG 100 mg
EUR 46

Heparin sodium salt

GC2310-1G 1 g
EUR 82

Heparin sodium salt

GC2310-250MG 250 mg
EUR 54

XTT sodium salt

GC5281-100MG 100 mg
EUR 205

XTT sodium salt

GC5281-250MG 250 mg
EUR 325

XTT sodium salt

GC5281-25MG 25 mg
EUR 94

XTT sodium salt

GC5281-50MG 50 mg
EUR 142

Casein sodium salt

GE5861-100G 100 g
EUR 43

Casein sodium salt

GE5861-1KG 1 kg
EUR 70

Casein sodium salt

GE5861-250G 250 g
EUR 47

Casein sodium salt

GE5861-500G 500 g
EUR 54

TAPS sodium salt

GB0912-100G 100 g
EUR 134

TAPS sodium salt

GB0912-25G 25 g
EUR 62

TAPS sodium salt

GB0912-500G 500 g
EUR 341

TAPSO sodium salt

GB1759-100G 100 g
EUR 134

TAPSO sodium salt

GB1759-25G 25 g
EUR 62

MES sodium salt

GB1926-100G 100 g
EUR 110

MES sodium salt

GB1926-25G 25 g
EUR 62

MOPSO sodium salt

GB3228-250G 250 g
EUR 150

TES sodium salt

GB4016-250G 250 g
EUR 269

TES sodium salt

GB4016-25G 25 g
EUR 70

CAPSO sodium salt

GB4515-250G 250 g
EUR 205

MOPS sodium salt

GB8397-250G 250 g
EUR 104

MOPS sodium salt

GB8397-25G 25 g
EUR 49

MOPS sodium salt

GB8397-500G 500 g
EUR 161

DIPSO sodium salt

GB8985-100G 100 g
EUR 329

DIPSO sodium salt

GB8985-25G 25 g
EUR 150

BES sodium salt

GB9133-100G 100 g
EUR 181

BES sodium salt

GB9133-250G 250 g
EUR 341

HEPES sodium salt

GB9181-100G 100 g
EUR 70

HEPES sodium salt

GB9181-1KG 1 kg
EUR 229

HEPES sodium salt

GB9181-25G 25 g
EUR 54
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