Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial.

Left ventricular (LV) dysfunction c-kit-positive, lineage-negative cardiac stem cells (CSC) improving post-infarction when given to animals. We conducted an experiment phase 1 (Stem Cell Infusion in Patients with ischemic cardiomyopathy [Scipio]) from autologous CSC for the treatment of heart failure due to ischemic heart disease.In trial stage A Scipio, patients with post-infarction LV dysfunction (ejection fraction [EF] ≤ 40%) prior to coronary artery bypass grafting were consecutively enrolled in the treatment and control groups. In stage B, patients were randomly assigned to treatment or control groups in a ratio of 2: 3 by using the block scheme of computer-generated randomization. 1 million autologous CSC given by intracoronary infusion at an average of 113 days (SE 4) after surgery; untreated controls.

Although this study is an open label, echocardiographic analysis did not know the duties of the group. The primary endpoint was a short-term security of CSC and the secondary endpoint was efficacy. A per-protocol analysis were used. This study is registered with ClinicalTrials.gov, number NCT00474461.This study is still in progress. 16 patients were assigned to the treatment group and seven for the control group; no side effects were reported related CSC.

On 14 CSC-treated patients were analyzed, LVEF increased from 30 · 3% (SE 1 · 9) before CSC infusion to 38 · 5% (2 · 8) at 4 months after infusion (p = 0 · 001). In contrast, the seven control patients, as long as the appropriate time interval, LVEF did not change (30 · 1% [2 · 4] at 4 months after CABG vs 30 · 2% [2 · 5] at 8 months after CABG). Importantly, CSC healthful effects are even more pronounced in the first year in eight patients (eg, LVEF increased by 12 · 3 unit ejection fraction [2 · 1] vs baseline, p = 0 · 0007).

In seven patients treated in whom cardiac MRI can be done, infarct size decreased from 32 · 6 g (6 · 3) by 7 · 8 g (1 · 7; 24%) at 4 months (p = 0 · 004) and 9 · 8 g (3 · 5; 30%) at 1 year (p = 0 · 04) .This preliminary results in patients with very encouraging. They suggest that intracoronary infusion of autologous CSC effective in improving LV systolic function and reduced infarct size in patients with heart failure after myocardial infarction, and warrant further, larger, phase 2 studies.University of Louisville Research Foundation and the National Institutes of Health ,

Luciferin D-, Firefly, Sodium Salt (4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic acid, D-Luciferin)
MBS639127-500mg 500mg
EUR 475

Luciferin D-, Firefly, Sodium Salt (4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic acid, D-Luciferin)
MBS639127-5x1g 5x1g
EUR 3200

(Rac)-Luciferin 6′-methyl ether (sodium)
HY-115749A Get quote Ask for price
Description: D-Luciferin 6′-methyl ether (6′-Methoxyluciferin; compound 19a) sodium is a potent luciferase from the North American firefly Photinus pyralis (PpyLuc) inhibitor with an IC50 of 0.1 μM. D-Luciferin 6′-methyl ether, a D-luciferin analog, shows non-specific interactions at ATP- and luciferin-binding sites of the PpyLuc active site[1].

D-Luciferin, SODIUM SALT
10102-1 50MG
EUR 86
Description: N/A

D-Luciferin, SODIUM SALT
10102-1-1 EA
EUR 232

D-Luciferin, SODIUM SALT
10102-2 1G
EUR 799
Description: N/A

D-Luciferin, SODIUM SALT
10102-2-1 EA
EUR 799

D-Luciferin, Sodium Salt
7902-100 each
EUR 144

D-Luciferin, Sodium Salt
7902-10G each
EUR 2890.8

D-Luciferin, Sodium Salt
7902-10PK each
EUR 3315.6

D-Luciferin, Sodium Salt
7902-1G each
EUR 424.8

D-Luciferin, Sodium Salt
7902-25G each Ask for price

D-Luciferin, Sodium Salt
7902-3PK each
EUR 1110

D-Luciferin, Sodium Salt
7902-50G each Ask for price

D-Luciferin, Sodium Salt
7902-5PK each
EUR 1795.2

D-Luciferin sodium salt
B8311-10 10 mg
EUR 40
Description: Probes & Dyes|Luciferase Substrates

D-Luciferin sodium salt
B8311-200 200 mg
EUR 344
Description: The substrate of firefly luciferase

D-Luciferin sodium salt
B8311-50 50 mg
EUR 128
Description: Probes & Dyes|Luciferase Substrates

D-Luciferin sodium salt
GP8979 25mg
EUR 284.45

D-Luciferin sodium salt
GP8979-100 100
EUR 310.6

D-Luciferin sodium salt
GP8979-25 25
EUR 113.1

D-Luciferin, sodium salt
E37F12509-1-g 1 g
EUR 1333
Description: Reagents for in vivo imaging.Bioluminescence reagent.

D-Luciferin, sodium salt
E37F12509-100-mg 100 mg
EUR 333
Description: Reagents for in vivo imaging.Bioluminescence reagent.

D-Luciferin, sodium salt
E37F12509-25-mg 25 mg
EUR 133
Description: Reagents for in vivo imaging.Bioluminescence reagent.

D-Luciferin sodium salt
MBS3846184-100mg 100mg
EUR 365

D-Luciferin sodium salt
MBS3846184-10mg 10mg
EUR 135

D-Luciferin sodium salt
MBS3846184-25mg 25mg
EUR 180

D-Luciferin sodium salt
MBS3846184-50mg 50mg
EUR 245

D-Luciferin sodium salt
MBS3846184-5x100mg 5x100mg
EUR 1630

D-Luciferin, sodium salt
MBS8579911-100mg 100mg
EUR 290

D-Luciferin, sodium salt
MBS8579911-1g 1g
EUR 835

D-Luciferin, sodium salt
MBS8579911-25mg 25mg
EUR 195

D-Luciferin, sodium salt
MBS8579911-5x100mg 5x100mg
EUR 1245

D-Luciferin, sodium salt
MBS8579911-5x25mg 5x25mg
EUR 820

D-Luciferin, Sodium Salt D
40901ES01 100 mg
EUR 195

D-Luciferin, Sodium Salt D
40901ES02 500 mg
EUR 365

D-Luciferin, Sodium Salt D
40901ES03 1 g
EUR 445

D-Luciferin Sodium Salt ex. Firefly, 99%
62851 25 Mg
EUR 40.95
Description: Part B

D-Luciferin,-sodium-salt
E37F12509 1-g
EUR 1333.33
Description: Reagents-for-in-vivo-imaging.Bioluminescence-reagent.

D-Luciferin, sodium salt *CAS#: 103404-75-7*
12509 25 mg
EUR 88
Description: Luciferin is the most popular and versatile bioluminescent substrate.

D-Luciferin, sodium salt *CAS#: 103404-75-7*
12509-25mg 25 mg
EUR 86
Description: Luciferin is the most popular and versatile bioluminescent substrate.

D-Luciferin, sodium salt *CAS#: 103404-75-7*
12510 100 mg
EUR 112
Description: Luciferin is the most popular and versatile bioluminescent substrate.

D-Luciferin, sodium salt *CAS#: 103404-75-7*
12510-100mg 100 mg
EUR 109
Description: Luciferin is the most popular and versatile bioluminescent substrate.

D-Luciferin, sodium salt *CAS#: 103404-75-7*
12511-1g 1 g
EUR 621
Description: Luciferin is the most popular and versatile bioluminescent substrate.

Luciferin D-, Firefly, Potassium Salt (4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic acid Potassium, D-Luciferin)
MBS639256-100mg 100mg
EUR 470

Luciferin D-, Firefly, Potassium Salt (4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic acid Potassium, D-Luciferin)
MBS639256-1g 1g
EUR 1040

Luciferin D-, Firefly, Potassium Salt (4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic acid Potassium, D-Luciferin)
MBS639256-500mg 500mg
EUR 680

Luciferin D-, Firefly, Potassium Salt (4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic acid Potassium, D-Luciferin)
MBS639256-50mg 50mg
EUR 290

Luciferin D-, Firefly, Potassium Salt (4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic acid Potassium, D-Luciferin)
MBS639256-5x1g 5x1g
EUR 4535

Luciferin
PCT1557-100MG 1 unit
EUR 318.64
Description: Luciferin

Luciferin
PCT1557-1G 1 unit
EUR 2760.87
Description: Luciferin

Luciferin
PCT1557-250MG 1 unit
EUR 764.83
Description: Luciferin

Luciferin
PCT1557-500MG 1 unit
EUR 1453.21
Description: Luciferin

Latia luciferin
MBS5782154-INQUIRE INQUIRE Ask for price

Latia luciferin
T32585-10mg 10mg Ask for price
Description: Latia luciferin

Latia luciferin
T32585-1g 1g Ask for price
Description: Latia luciferin

Latia luciferin
T32585-1mg 1mg Ask for price
Description: Latia luciferin

Latia luciferin
T32585-50mg 50mg Ask for price
Description: Latia luciferin

Latia luciferin
T32585-5mg 5mg Ask for price
Description: Latia luciferin

Cypridina luciferin
MBS5780774-INQUIRE INQUIRE Ask for price

Cypridina luciferin
T31154-10mg 10mg Ask for price
Description: Cypridina luciferin

Cypridina luciferin
T31154-1g 1g Ask for price
Description: Cypridina luciferin

Cypridina luciferin
T31154-1mg 1mg Ask for price
Description: Cypridina luciferin

Cypridina luciferin
T31154-50mg 50mg Ask for price
Description: Cypridina luciferin

Cypridina luciferin
T31154-5mg 5mg Ask for price
Description: Cypridina luciferin

2,4-D (sodium salt)
HY-18572A Get quote Ask for price
Description: 2,4-D sodium salt (Sodium 2,4-dichlorophenoxyacetate) is a selective herbicide that can be orally active for the control of broad-leaved weeds. 2,4-D sodium salt can induce apoptosis. 2,4-D sodium salt inhibits DNA and protein synthesis, thereby preventing normal plant growth and development[1][2][3].

2,4-D sodium salt
MBS5800588-5mg 5(mg
EUR 915

2,4-D sodium salt
MBS5800588-5x5mg 5x5(mg
EUR 3970

2,4-D sodium salt
T40324-10mg 10mg Ask for price
Description: 2,4-D sodium salt

2,4-D sodium salt
T40324-1g 1g Ask for price
Description: 2,4-D sodium salt

2,4-D sodium salt
T40324-1mg 1mg Ask for price
Description: 2,4-D sodium salt

2,4-D sodium salt
T40324-50mg 50mg Ask for price
Description: 2,4-D sodium salt

2,4-D sodium salt
T40324-5mg 5mg Ask for price
Description: 2,4-D sodium salt

d-Cloprostenol Sodium Salt
C587330 10mg
EUR 293
Description: 62561-03-9

D-Luciferin Sodium
540277 50.0mg
EUR 180

D-Luciferin (sodium)
HY-12591 50mg
EUR 37.88
Description: D-luciferin is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP[1]. We of er the firefly luciferase (HY-P1004), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B) .

D-Luciferin Sodium
MBS5756192-100mg 100mg
EUR 190

D-Luciferin Sodium
MBS5756192-10mg 10mg
EUR 145

D-Luciferin Sodium
MBS5756192-200mg 200mg
EUR 240

D-Luciferin Sodium
MBS5756192-50mg 50mg
EUR 160

D-Luciferin Sodium
MBS5756192-5x200mg 5x200mg
EUR 920

D-Luciferin Sodium
T19743-10mg 10mg Ask for price
Description: D-Luciferin Sodium

D-Luciferin Sodium
T19743-1g 1g Ask for price
Description: D-Luciferin Sodium

D-Luciferin Sodium
T19743-1mg 1mg Ask for price
Description: D-Luciferin Sodium

D-Luciferin Sodium
T19743-50mg 50mg Ask for price
Description: D-Luciferin Sodium

D-Luciferin Sodium
T19743-5mg 5mg Ask for price
Description: D-Luciferin Sodium

Luciferin-O-galactopyranoside
MBS5782492-5mg 5(mg
EUR 915

Luciferin-O-galactopyranoside
MBS5782492-5x5mg 5x5(mg
EUR 3970

Luciferin-O-galactopyranoside
T32927-10mg 10mg Ask for price
Description: Luciferin-O-galactopyranoside

Luciferin-O-galactopyranoside
T32927-1g 1g Ask for price
Description: Luciferin-O-galactopyranoside

Luciferin-O-galactopyranoside
T32927-1mg 1mg Ask for price
Description: Luciferin-O-galactopyranoside

Luciferin-O-galactopyranoside
T32927-50mg 50mg Ask for price
Description: Luciferin-O-galactopyranoside

Luciferin-O-galactopyranoside
T32927-5mg 5mg Ask for price
Description: Luciferin-O-galactopyranoside

D,L-Alanosine Sodium Salt
A510795 250mg
EUR 161

D-Mannuronic Acid Sodium Salt
D208470 1g
EUR 1200
Description: 921-56-2

Luciferase (Luciferin 4-monooxygenase) (PE)
MBS6251982-01mL 0.1(mL
EUR 875

Luciferase (Luciferin 4-monooxygenase) (PE)
MBS6251982-5x01mL 5x0.1mL
EUR 3790

Luciferase (Luciferin 4-monooxygenase) (AP)
MBS6248097-01mL 0.1(mL
EUR 875

Luciferase (Luciferin 4-monooxygenase) (AP)
MBS6248097-5x01mL 5x0.1mL
EUR 3790

D-Pantothenic Acid Sodium Salt
41600203-1 25 g
EUR 84.59

D-Pantothenic Acid Sodium Salt
41600203-2 100 g
EUR 217.69

D-Pantothenic Acid Sodium Salt
26004-02 25G
EUR 39.2

D-Pantothenic Acid Sodium Salt
26004-44 5G
EUR 19.25

D-Pantothenic acid sodium salt
MBS3609193-100mg 100mg
EUR 200

D-Pantothenic acid sodium salt
MBS3609193-200mg 200mg
EUR 225

D-Pantothenic acid sodium salt
MBS3609193-5x200mg 5x200mg
EUR 695

D-Pantothenic acid sodium salt
MBS578469-100mg 100mg
EUR 145

D-Pantothenic acid sodium salt
MBS578469-200mg 200mg
EUR 160

D-Pantothenic acid sodium salt
MBS578469-25mg 25mg
EUR 120

D-Pantothenic acid sodium salt
MBS578469-50mg 50mg
EUR 135

D-Pantothenic acid sodium salt
MBS578469-5x200mg 5x200mg
EUR 580

D-Pantothenic Acid Sodium Salt
P190308 2.5g
EUR 80
Description: 867-81-2

Luciferin 4-monooxygenase Antibody
CSB-PA635630XA01FUR-02mg 0.2mg Ask for price
Description: Recombinant Luciola mingrelica (Southern Russian firefly) Luciferin 4-monooxygenase protein

Luciferin 4-monooxygenase Antibody
CSB-PA635630XA01FUR-10mg 10mg Ask for price
Description: Recombinant Luciola mingrelica (Southern Russian firefly) Luciferin 4-monooxygenase protein

Luciferin 4-monooxygenase Antibody
CSB-PA886349XA01FUO-02mg 0.2mg Ask for price
Description: Recombinant Aquatica lateralis (Heike firefly) (Luciola lateralis) Luciferin 4-monooxygenase protein

Luciferin 4-monooxygenase Antibody
CSB-PA886349XA01FUO-10mg 10mg Ask for price
Description: Recombinant Aquatica lateralis (Heike firefly) (Luciola lateralis) Luciferin 4-monooxygenase protein

Luciferin 4-monooxygenase Antibody
MBS7191896-INQUIRE INQUIRE Ask for price

Luciferin 4-monooxygenase Antibody
MBS9012202-INQUIRE INQUIRE Ask for price

Neridronate, Sodium Salt (Nerixia Sodium Salt)
MBS6080862-10mg 10(mg
EUR 485

Neridronate, Sodium Salt (Nerixia Sodium Salt)
MBS6080862-5x10mg 5x10mg
EUR 2025

D-Galacturonic acid sodium salt
GC4898 5g
EUR 2061.32

D-Galacturonic acid sodium salt
GC4898-25 25
EUR 318.6

D-Galacturonic acid sodium salt
GC4898-250 250
EUR 1960.5

D-Galacturonic acid sodium salt
GC4898-5 5
EUR 135.7

D-(-)-Norgestrel Sulfate Sodium Salt
N689520 100mg
EUR 222

Luciferase (Luciferin 4-monooxygenase) (HRP)
MBS6251032-01mL 0.1(mL
EUR 875

Luciferase (Luciferin 4-monooxygenase) (HRP)
MBS6251032-5x01mL 5x0.1mL
EUR 3790

Luciferase (Luciferin 4-monooxygenase) (APC)
MBS6268951-01mL 0.1mL
EUR 875

Luciferase (Luciferin 4-monooxygenase) (APC)
MBS6268951-5x01mL 5x0.1mL
EUR 3790

Luciferase (Luciferin 4-monooxygenase) (FITC)
MBS6250028-01mL 0.1(mL
EUR 875

Luciferase (Luciferin 4-monooxygenase) (FITC)
MBS6250028-5x01mL 5x0.1mL
EUR 3790

alpha-D-Thiomannose Sodium Salt
A576078 100mg
EUR 1800
Description: 111057-34-2

Aniline D-Glucuronide Sodium Salt
A662500 10mg
EUR 782
Description: 116866-42-3

Luciferase (Luciferin 4-monooxygenase) (Biotin)
MBS6249111-01mL 0.1(mL
EUR 875

Luciferase (Luciferin 4-monooxygenase) (Biotin)
MBS6249111-5x01mL 5x0.1mL
EUR 3790

D-Mannopyranuronic acid, sodium salt
GC5971 10mg
EUR 1323

D-Mannopyranuronic acid, sodium salt
GC5971-10 10
EUR 344.8

D-Mannopyranuronic acid, sodium salt
GC5971-100 100
EUR 1444.9

D-Mannopyranuronic acid, sodium salt
GC5971-25 25
EUR 624.6

D-Mannopyranuronic acid, sodium salt
GC5971-50 50
EUR 932.2

D-Glucuronic Acid, Sodium salt Monohydrate (Sodium D-Glucuronate)
MBS651816-100g 100g
EUR 610

D-Glucuronic Acid, Sodium salt Monohydrate (Sodium D-Glucuronate)
MBS651816-10g 10g
EUR 280

D-Glucuronic Acid, Sodium salt Monohydrate (Sodium D-Glucuronate)
MBS651816-25g 25g
EUR 380

D-Glucuronic Acid, Sodium salt Monohydrate (Sodium D-Glucuronate)
MBS651816-5x100g 5x100g
EUR 2600

Coelenterazine, native (Luciferin, Preluciferin)
MBS654174-1mg 1mg
EUR 560

Coelenterazine, native (Luciferin, Preluciferin)
MBS654174-5x1mg 5x1mg
EUR 2375

UDP-β-D-Glucose (sodium salt)
T37899-10mg 10mg Ask for price
Description: UDP-β-D-Glucose (sodium salt)

UDP-β-D-Glucose (sodium salt)
T37899-1g 1g Ask for price
Description: UDP-β-D-Glucose (sodium salt)

UDP-β-D-Glucose (sodium salt)
T37899-1mg 1mg Ask for price
Description: UDP-β-D-Glucose (sodium salt)

UDP-β-D-Glucose (sodium salt)
T37899-50mg 50mg Ask for price
Description: UDP-β-D-Glucose (sodium salt)

UDP-β-D-Glucose (sodium salt)
T37899-5mg 5mg Ask for price
Description: UDP-β-D-Glucose (sodium salt)

1-Thio-D-Glucose Sodium Salt
T11015 1G
EUR 764.66
Description: CAS N° 62778-20-5

UDP-beta-D-Glucose (sodium salt)
MBS5798685-100mg 100(mg
EUR 150

UDP-beta-D-Glucose (sodium salt)
MBS5798685-500mg 500mg
EUR 315

UDP-beta-D-Glucose (sodium salt)
MBS5798685-5x500mg 5x500(mg
EUR 1265

Luciferase (Luciferin 4-monooxygenase) (MaxLight 405)
MBS6253006-01mL 0.1(mL
EUR 875

Luciferase (Luciferin 4-monooxygenase) (MaxLight 405)
MBS6253006-5x01mL 5x0.1mL
EUR 3790
Scroll to Top