Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial.

Left ventricular (LV) dysfunction c-kit-positive, lineage-negative cardiac stem cells (CSC) improving post-infarction when given to animals. We conducted an experiment phase 1 (Stem Cell Infusion in Patients with ischemic cardiomyopathy [Scipio]) from autologous CSC for the treatment of heart failure due to ischemic heart disease.In trial stage A Scipio, patients with post-infarction LV dysfunction (ejection fraction [EF] ≤ 40%) prior to coronary artery bypass grafting were consecutively enrolled in the treatment and control groups. In stage B, patients were randomly assigned to treatment or control groups in a ratio of 2: 3 by using the block scheme of computer-generated randomization. 1 million autologous CSC given by intracoronary infusion at an average of 113 days (SE 4) after surgery; untreated controls.

Although this study is an open label, echocardiographic analysis did not know the duties of the group. The primary endpoint was a short-term security of CSC and the secondary endpoint was efficacy. A per-protocol analysis were used. This study is registered with ClinicalTrials.gov, number NCT00474461.This study is still in progress. 16 patients were assigned to the treatment group and seven for the control group; no side effects were reported related CSC.

On 14 CSC-treated patients were analyzed, LVEF increased from 30 · 3% (SE 1 · 9) before CSC infusion to 38 · 5% (2 · 8) at 4 months after infusion (p = 0 · 001). In contrast, the seven control patients, as long as the appropriate time interval, LVEF did not change (30 · 1% [2 · 4] at 4 months after CABG vs 30 · 2% [2 · 5] at 8 months after CABG). Importantly, CSC healthful effects are even more pronounced in the first year in eight patients (eg, LVEF increased by 12 · 3 unit ejection fraction [2 · 1] vs baseline, p = 0 · 0007).

In seven patients treated in whom cardiac MRI can be done, infarct size decreased from 32 · 6 g (6 · 3) by 7 · 8 g (1 · 7; 24%) at 4 months (p = 0 · 004) and 9 · 8 g (3 · 5; 30%) at 1 year (p = 0 · 04) .This preliminary results in patients with very encouraging. They suggest that intracoronary infusion of autologous CSC effective in improving LV systolic function and reduced infarct size in patients with heart failure after myocardial infarction, and warrant further, larger, phase 2 studies.University of Louisville Research Foundation and the National Institutes of Health ,

D-Luciferin sodium salt

B8311-10 10 mg
EUR 131

D-Luciferin sodium salt

B8311-200 200 mg
EUR 699

D-Luciferin sodium salt

B8311-50 50 mg
EUR 293

D-Luciferin, Sodium Salt

7902-100
EUR 120

D-Luciferin, Sodium Salt

7902-10G
EUR 2409

D-Luciferin, Sodium Salt

7902-10PK
EUR 2763

D-Luciferin, Sodium Salt

7902-1G
EUR 354

D-Luciferin, Sodium Salt

7902-25G Ask for price

D-Luciferin, Sodium Salt

7902-3PK
EUR 925

D-Luciferin, Sodium Salt

7902-50G Ask for price

D-Luciferin, Sodium Salt

7902-5PK
EUR 1496

D-Luciferin potassium salt

HY-12591B 50mg
EUR 153

D-Luciferin, Potassium Salt

D0510-010 100mg
EUR 185

D-Luciferin, Potassium Salt

D0510-050 500mg
EUR 504

D-Luciferin, Potassium Salt

D0510-100 1g
EUR 847

D-Luciferin, potassium salt

10101 10MG
EUR 112
Description: Minimum order quantity: 1 unit of 10MG

D-Luciferin, potassium salt

10101-1 50MG
EUR 234
Description: Minimum order quantity: 1 unit of 50MG

D-Luciferin, potassium salt

10101-2 1G
EUR 714
Description: Minimum order quantity: 1 unit of 1G

D-Luciferin, Potassium Salt

7903-100
EUR 120

D-Luciferin, Potassium Salt

7903-10G
EUR 2409

D-Luciferin, Potassium Salt

7903-10PK
EUR 2763

D-Luciferin, Potassium Salt

7903-1G
EUR 354

D-Luciferin, Potassium Salt

7903-25G Ask for price

D-Luciferin, Potassium Salt

7903-3PK
EUR 925

D-Luciferin, Potassium Salt

7903-50G Ask for price

D-Luciferin, Potassium Salt

7903-5PK
EUR 1496

D-Luciferin, sodium salt *CAS#: 103404-75-7*

12509 25 mg
EUR 115

D-Luciferin, sodium salt *CAS#: 103404-75-7*

12510 100 mg
EUR 132

D-Luciferin, sodium salt *CAS#: 103404-75-7*

12511 1 g
EUR 528

EZSolution? D-Luciferin, Potassium Salt

B3001-set
EUR 370

Brite-Light? D-Luciferin, Potassium Salt

B3000-10PK
EUR 2268

Brite-Light? D-Luciferin, Potassium Salt

B3000-1G
EUR 327

Brite-Light? D-Luciferin, Potassium Salt

B3000-5PK
EUR 1300

D-Luciferin

HY-12591A 10mg
EUR 108

D-Luciferin

GP9319-100MG 100 mg
EUR 221

D-Luciferin

GP9319-10MG 10 mg
EUR 70

D-Luciferin

GP9319-25MG 25 mg
EUR 110

D-Luciferin

GP9319-50MG 50 mg
EUR 150

D-Luciferin

B6040-10 10 mg
EUR 131
Description: D-luciferin is a cell-permeable chemiluminescent luciferase substrate with a Km of approximately 2 ?M. D-luciferin could emit lights upon oxidative decarboxylation in the presence of ATP.

D-Luciferin

B6040-200 200 mg
EUR 699
Description: D-luciferin is a cell-permeable chemiluminescent luciferase substrate with a Km of approximately 2 ?M. D-luciferin could emit lights upon oxidative decarboxylation in the presence of ATP.

D-Luciferin

B6040-50 50 mg
EUR 293
Description: D-luciferin is a cell-permeable chemiluminescent luciferase substrate with a Km of approximately 2 ?M. D-luciferin could emit lights upon oxidative decarboxylation in the presence of ATP.

D-Luciferin, potassium salt *CAS#: 115144-35-9*

12505 25 mg
EUR 115

D-Luciferin, potassium salt *CAS#: 115144-35-9*

12506 100 mg
EUR 132

D-Luciferin, potassium salt *CAS#: 115144-35-9*

12507 1 g
EUR 263

D-Luciferin acetate

12516 5 mg
EUR 219

D-Glucuronic acid, sodium salt, monohydrate

GB0483 5g
EUR 107.42

Methyl beta-D-glucuronide sodium salt

GC4190-1G 1 g
EUR 229

Methyl beta-D-glucuronide sodium salt

GC4190-250MG 250 mg
EUR 110

D-Glucuronic acid sodium salt monohydrate

GC8431-100G 100 g
EUR 126

D-Glucuronic acid sodium salt monohydrate

GC8431-250G 250 g
EUR 229

D-Glucuronic acid sodium salt monohydrate

GC8431-25G 25 g
EUR 70

D-Glucuronic acid sodium salt monohydrate

GC8431-5G 5 g
EUR 46

D-Glucosamine 2-sulfate sodium salt

GC9126-25MG 25 mg
EUR 61

Estradiol 17-(?-D-Glucuronide) (sodium salt)

C3840-5 5 mg
EUR 132
Description: Km: 75 ?MEstradiol 17-(?-D-Glucuronide) is a substrate of the multidrug resistance protein 2 (MRP2).MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes.

Estradiol 17-(?-D-Glucuronide) (sodium salt)

C3840-10 10 mg
EUR 206
Description: Km: 75 ?MEstradiol 17-(?-D-Glucuronide) is a substrate of the multidrug resistance protein 2 (MRP2).MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes.

Estradiol 17-(?-D-Glucuronide) (sodium salt)

C3840-25 25 mg
EUR 338
Description: Km: 75 ?MEstradiol 17-(?-D-Glucuronide) is a substrate of the multidrug resistance protein 2 (MRP2).MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes.

Estradiol 17-(?-D-Glucuronide) (sodium salt)

C3840-50 50 mg
EUR 502
Description: Km: 75 ?MEstradiol 17-(?-D-Glucuronide) is a substrate of the multidrug resistance protein 2 (MRP2).MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes.

Estradiol 3-(?-D-Glucuronide) (sodium salt)

C3897-1 1 mg
EUR 118
Description: ?-estradiol 3-(?-d-glucuronide) (E23G) is a noncholestatic regioisomer of the estrogen metabolite, E217G (?-Estradiol 17-(?-d-glucuronide)) [1]. E23G functions as a substrate for multidrug resistance associated protein 2 (MRP2) [2].

Estradiol 3-(?-D-Glucuronide) (sodium salt)

C3897-10 10 mg
EUR 527
Description: ?-estradiol 3-(?-d-glucuronide) (E23G) is a noncholestatic regioisomer of the estrogen metabolite, E217G (?-Estradiol 17-(?-d-glucuronide)) [1]. E23G functions as a substrate for multidrug resistance associated protein 2 (MRP2) [2].

Estradiol 3-(?-D-Glucuronide) (sodium salt)

C3897-25 25 mg
EUR 1073
Description: ?-estradiol 3-(?-d-glucuronide) (E23G) is a noncholestatic regioisomer of the estrogen metabolite, E217G (?-Estradiol 17-(?-d-glucuronide)) [1]. E23G functions as a substrate for multidrug resistance associated protein 2 (MRP2) [2].

Estradiol 3-(?-D-Glucuronide) (sodium salt)

C3897-5 5 mg
EUR 306
Description: ?-estradiol 3-(?-d-glucuronide) (E23G) is a noncholestatic regioisomer of the estrogen metabolite, E217G (?-Estradiol 17-(?-d-glucuronide)) [1]. E23G functions as a substrate for multidrug resistance associated protein 2 (MRP2) [2].

D-Luciferin, free acid

10100 10MG
EUR 112
Description: Minimum order quantity: 1 unit of 10MG

D-Luciferin, free acid

10100-1 50MG
EUR 234
Description: Minimum order quantity: 1 unit of 50MG

D-Luciferin, free acid

10100-2 1G
EUR 714
Description: Minimum order quantity: 1 unit of 1G

D-Luciferin (Free acid)

2779-1000
EUR 338

D-Luciferin (Free acid)

2779-250
EUR 175

D-Luciferin (Free acid)

2779-500
EUR 251

D-Luciferin (Free acid)

2779-5000
EUR 1273

Cromolyn sodium salt

SB0843 5g
EUR 65.66

Methotrexate sodium salt

M031-250MG 250 mg
EUR 117

Monensin Sodium Salt

M083-1G 1 g
EUR 71

Monensin Sodium Salt

M083-5x1G 5 x 1 g
EUR 159

MES, sodium salt

MB0611 50g
EUR 74.36

MOPSO, sodium salt

MDB0095 25g
EUR 63.92

MOPS, sodium salt

MDB360S 100g
EUR 89.15

Entacapone (sodium salt)

HY-14280A 10mg
EUR 119

Grazoprevir sodium salt

HY-15298C 10mg
EUR 243

Luminol (sodium salt)

HY-15922A 500mg
EUR 108

Salinomycin (sodium salt)

HY-17439 100mg
EUR 187

Heparin (sodium salt)

HY-17567A 500mg
EUR 147

Seladelpar sodium salt

HY-19522A 10mM/1mL
EUR 163

Etomoxir (sodium salt)

HY-50202A 5mg
EUR 147

Silmitasertib (sodium salt)

HY-50855B 10mg
EUR 187

Cefotaxime (sodium salt)

HY-A0088 10mM/1mL
EUR 113

Adapalene (sodium salt)

HY-B0091A 500mg
EUR 326

Cefoperazone (sodium salt)

HY-B0210A 500mg
EUR 108

Sulfamerazine (sodium salt)

HY-B0512A 500mg
EUR 131

Azlocillin (sodium salt)

HY-B0529A 500mg
EUR 113

Ceftriaxone (sodium salt)

HY-B0712B 500mg
EUR 173

Citicoline sodium salt

HY-B0739A 100mg
EUR 108

Bucladesine (sodium salt)

HY-B0764 50mg
EUR 139

Cloprostenol sodium salt

HY-108415 10mg
EUR 349

Fosmidomycin sodium salt

HY-112853 5mg
EUR 349

Zidebactam sodium salt

HY-120859A 10mg
EUR 1025

Resorufin sodium salt

HY-123533A 100mg
EUR 142

Batimastat (sodium salt)

HY-13564A 5mg
EUR 187

HEPES, sodium salt

HB0265 50g
EUR 65.66

HEPPSO, sodium salt

HB0496 25g
EUR 97.85

Nigericin (sodium salt)

HY-100381 100mg
EUR 725

Setogepram (sodium salt)

HY-100775 10mM/1mL
EUR 327

GJ103 (sodium salt)

HY-101203A 10mM/1mL
EUR 142

Moniliformin (sodium salt)

HY-101905 1mg
EUR 312

Danshensu (sodium salt)

HY-N0106 200mg
EUR 291

Monensin sodium salt

HY-N0150 100mg
EUR 108

XTT, sodium salt

PB2525 250mg
EUR 269.24

PIPES, sodium salt

PDB0434 100g
EUR 88.28

Suramin (sodium salt)

HY-B0879A 50mg
EUR 394

Zomepirac (sodium salt)

HY-B0890 500mg
EUR 160

Oxacillin (sodium salt)

HY-B0925 100mg
EUR 119

Methicillin (sodium salt)

HY-B0974 10mM/1mL
EUR 126

Sulfaquinoxaline sodium salt

HY-B1282A 100mg
EUR 119

Lorglumide sodium salt

HY-B1439B 5mg
EUR 119

Moxalactam (sodium salt)

HY-B1484 200mg
EUR 147

DIDS sodium salt

HY-D0086 50mg
EUR 142

NADP (sodium salt)

HY-F0002 500mg
EUR 271

TAPS, sodium salt

TB0920 50g
EUR 71.75

TAPSO, sodium salt

TB0922 50g
EUR 102.2

MES sodium salt

GB1926-10G 10 g
EUR 50

MES sodium salt

GB1926-250G 250 g
EUR 181

MES sodium salt

GB1926-500G 500 g
EUR 298

MOPSO sodium salt

GB3228-100G 100 g
EUR 94

MOPSO sodium salt

GB3228-25G 25 g
EUR 58

MOPSO sodium salt

GB3228-500G 500 g
EUR 229

TES sodium salt

GB4016-100G 100 g
EUR 150

TES sodium salt

GB4016-500G 500 g
EUR 429

CAPSO sodium salt

GB4515-100G 100 g
EUR 110

CAPSO sodium salt

GB4515-25G 25 g
EUR 54

CAPSO sodium salt

GB4515-500G 500 g
EUR 309

MOPS sodium salt

GB8397-100G 100 g
EUR 66

MOPS sodium salt

GB8397-1KG 1 kg
EUR 257

DIPSO sodium salt

GB8985-250G 250 g
EUR 628

BES sodium salt

GB9133-25G 25 g
EUR 86

HEPES sodium salt

GB9181-250G 250 g
EUR 99

HEPES sodium salt

GB9181-500G 500 g
EUR 150

Heparin sodium salt

GC2310-100MG 100 mg
EUR 46

Heparin sodium salt

GC2310-1G 1 g
EUR 82

Heparin sodium salt

GC2310-250MG 250 mg
EUR 54

XTT sodium salt

GC5281-100MG 100 mg
EUR 205

XTT sodium salt

GC5281-250MG 250 mg
EUR 325

XTT sodium salt

GC5281-25MG 25 mg
EUR 94

XTT sodium salt

GC5281-50MG 50 mg
EUR 142

Casein sodium salt

GE5861-100G 100 g
EUR 43

Casein sodium salt

GE5861-1KG 1 kg
EUR 70

Casein sodium salt

GE5861-250G 250 g
EUR 47

Casein sodium salt

GE5861-500G 500 g
EUR 54

TAPS sodium salt

GB0912-100G 100 g
EUR 134

TAPS sodium salt

GB0912-25G 25 g
EUR 62

TAPS sodium salt

GB0912-500G 500 g
EUR 341

TAPSO sodium salt

GB1759-100G 100 g
EUR 134

TAPSO sodium salt

GB1759-25G 25 g
EUR 62

MES sodium salt

GB1926-100G 100 g
EUR 110

MES sodium salt

GB1926-25G 25 g
EUR 62

MOPSO sodium salt

GB3228-250G 250 g
EUR 150

TES sodium salt

GB4016-250G 250 g
EUR 269

TES sodium salt

GB4016-25G 25 g
EUR 70
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