Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial.

Left ventricular (LV) dysfunction c-kit-positive, lineage-negative cardiac stem cells (CSC) improving post-infarction when given to animals. We conducted an experiment phase 1 (Stem Cell Infusion in Patients with ischemic cardiomyopathy [Scipio]) from autologous CSC for the treatment of heart failure due to ischemic heart disease.In trial stage A Scipio, patients with post-infarction LV dysfunction (ejection fraction [EF] ≤ 40%) prior to coronary artery bypass grafting were consecutively enrolled in the treatment and control groups. In stage B, patients were randomly assigned to treatment or control groups in a ratio of 2: 3 by using the block scheme of computer-generated randomization. 1 million autologous CSC given by intracoronary infusion at an average of 113 days (SE 4) after surgery; untreated controls.

Although this study is an open label, echocardiographic analysis did not know the duties of the group. The primary endpoint was a short-term security of CSC and the secondary endpoint was efficacy. A per-protocol analysis were used. This study is registered with ClinicalTrials.gov, number NCT00474461.This study is still in progress. 16 patients were assigned to the treatment group and seven for the control group; no side effects were reported related CSC.

On 14 CSC-treated patients were analyzed, LVEF increased from 30 · 3% (SE 1 · 9) before CSC infusion to 38 · 5% (2 · 8) at 4 months after infusion (p = 0 · 001). In contrast, the seven control patients, as long as the appropriate time interval, LVEF did not change (30 · 1% [2 · 4] at 4 months after CABG vs 30 · 2% [2 · 5] at 8 months after CABG). Importantly, CSC healthful effects are even more pronounced in the first year in eight patients (eg, LVEF increased by 12 · 3 unit ejection fraction [2 · 1] vs baseline, p = 0 · 0007).

In seven patients treated in whom cardiac MRI can be done, infarct size decreased from 32 · 6 g (6 · 3) by 7 · 8 g (1 · 7; 24%) at 4 months (p = 0 · 004) and 9 · 8 g (3 · 5; 30%) at 1 year (p = 0 · 04) .This preliminary results in patients with very encouraging. They suggest that intracoronary infusion of autologous CSC effective in improving LV systolic function and reduced infarct size in patients with heart failure after myocardial infarction, and warrant further, larger, phase 2 studies.University of Louisville Research Foundation and the National Institutes of Health ,

D-Luciferin sodium salt

B8311-200 200 mg
EUR 838.8

D-Luciferin sodium salt

B8311-50 50 mg
EUR 351.6

D-Luciferin, Sodium Salt

7902-100 each
EUR 144

D-Luciferin, Sodium Salt

7902-10G each
EUR 2890.8

D-Luciferin, Sodium Salt

7902-10PK each
EUR 3315.6

D-Luciferin, Sodium Salt

7902-1G each
EUR 424.8

D-Luciferin, Sodium Salt

7902-25G each Ask for price

D-Luciferin, Sodium Salt

7902-3PK each
EUR 1110

D-Luciferin, Sodium Salt

7902-50G each Ask for price

D-Luciferin, Sodium Salt

7902-5PK each
EUR 1795.2

D-Luciferin (sodium salt)

HY-12591 50mg
EUR 183.6

D-Luciferin sodium salt

GP8979-100 100
EUR 310.6

D-Luciferin sodium salt

GP8979-25 25
EUR 113.1

D-Luciferin, sodium salt *CAS#: 103404-75-7*

12509 25 mg
EUR 86

D-Luciferin, sodium salt *CAS#: 103404-75-7*

12510 100 mg
EUR 109

D-Luciferin, sodium salt *CAS#: 103404-75-7*

12511 1 g
EUR 621

D-Luciferin, sodium salt *CAS#: 103404-75-7*

12509-25mg 25 mg
EUR 86
Description: Luciferin is the most popular and versatile bioluminescent substrate.

D-Luciferin, sodium salt *CAS#: 103404-75-7*

12510-100mg 100 mg
EUR 109
Description: Luciferin is the most popular and versatile bioluminescent substrate.

D-Luciferin, sodium salt *CAS#: 103404-75-7*

12511-1g 1 g
EUR 621
Description: Luciferin is the most popular and versatile bioluminescent substrate.

D-Galacturonic acid sodium salt

GC4898-25 25
EUR 318.6

D-Galacturonic acid sodium salt

GC4898-250 250
EUR 1960.5

D-Galacturonic acid sodium salt

GC4898-5 5
EUR 135.7

D-Mannopyranuronic acid, sodium salt

GC5971-10 10
EUR 344.8

D-Mannopyranuronic acid, sodium salt

GC5971-100 100
EUR 1444.9

D-Mannopyranuronic acid, sodium salt

GC5971-25 25
EUR 624.6

D-Mannopyranuronic acid, sodium salt

GC5971-50 50
EUR 932.2

D-Glucosamine 2-sulfate sodium salt

GC9126-25MG 25 mg
EUR 73.2

D-Glucosamine 2-sulfate sodium salt

GC9126-25 25
EUR 30.9

Estradiol 17-(?-D-Glucuronide) (sodium salt)

C3840-10 10 mg
EUR 247.2
Description: Km: 75 ?MEstradiol 17-(?-D-Glucuronide) is a substrate of the multidrug resistance protein 2 (MRP2).MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes.

Estradiol 17-(?-D-Glucuronide) (sodium salt)

C3840-25 25 mg
EUR 405.6
Description: Km: 75 ?MEstradiol 17-(?-D-Glucuronide) is a substrate of the multidrug resistance protein 2 (MRP2).MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes.

Estradiol 17-(?-D-Glucuronide) (sodium salt)

C3840-5 5 mg
EUR 158.4
Description: Km: 75 ?MEstradiol 17-(?-D-Glucuronide) is a substrate of the multidrug resistance protein 2 (MRP2).MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes.

Estradiol 17-(?-D-Glucuronide) (sodium salt)

C3840-50 50 mg
EUR 602.4
Description: Km: 75 ?MEstradiol 17-(?-D-Glucuronide) is a substrate of the multidrug resistance protein 2 (MRP2).MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes.

Estradiol 3-(?-D-Glucuronide) (sodium salt)

C3897-1 1 mg
EUR 141.6
Description: ?-estradiol 3-(?-d-glucuronide) (E23G) is a noncholestatic regioisomer of the estrogen metabolite, E217G (?-Estradiol 17-(?-d-glucuronide)) [1]. E23G functions as a substrate for multidrug resistance associated protein 2 (MRP2) [2].

Estradiol 3-(?-D-Glucuronide) (sodium salt)

C3897-10 10 mg
EUR 632.4
Description: ?-estradiol 3-(?-d-glucuronide) (E23G) is a noncholestatic regioisomer of the estrogen metabolite, E217G (?-Estradiol 17-(?-d-glucuronide)) [1]. E23G functions as a substrate for multidrug resistance associated protein 2 (MRP2) [2].

Estradiol 3-(?-D-Glucuronide) (sodium salt)

C3897-25 25 mg
EUR 1287.6
Description: ?-estradiol 3-(?-d-glucuronide) (E23G) is a noncholestatic regioisomer of the estrogen metabolite, E217G (?-Estradiol 17-(?-d-glucuronide)) [1]. E23G functions as a substrate for multidrug resistance associated protein 2 (MRP2) [2].

Estradiol 3-(?-D-Glucuronide) (sodium salt)

C3897-5 5 mg
EUR 367.2
Description: ?-estradiol 3-(?-d-glucuronide) (E23G) is a noncholestatic regioisomer of the estrogen metabolite, E217G (?-Estradiol 17-(?-d-glucuronide)) [1]. E23G functions as a substrate for multidrug resistance associated protein 2 (MRP2) [2].

Methyl beta-D-glucuronide sodium salt

GC4190-1G 1 g
EUR 274.8

Methyl beta-D-glucuronide sodium salt

GC4190-250MG 250 mg
EUR 132

MES SODIUM SALT

213002 each Ask for price

XTT, sodium salt

PB2525 250mg
EUR 323.09

MES, sodium salt

MB0611 50g
EUR 89.23

XTT sodium salt

GC5281-100MG 100 mg
EUR 246

XTT sodium salt

GC5281-250MG 250 mg
EUR 390

XTT sodium salt

GC5281-25MG 25 mg
EUR 112.8

XTT sodium salt

GC5281-50MG 50 mg
EUR 170.4

MES sodium salt

GB1926-100G 100 g
EUR 132

MES sodium salt

GB1926-10G 10 g
EUR 60

MES sodium salt

GB1926-250G 250 g
EUR 217.2

MES sodium salt

GB1926-25G 25 g
EUR 74.4

MES sodium salt

GB1926-500G 500 g
EUR 357.6

TES sodium salt

GB4016-100G 100 g
EUR 180

TES sodium salt

GB4016-250G 250 g
EUR 322.8

TES sodium salt

GB4016-25G 25 g
EUR 84

TES sodium salt

GB4016-500G 500 g
EUR 514.8

BES sodium salt

GB9133-100G 100 g
EUR 217.2

BES sodium salt

GB9133-250G 250 g
EUR 409.2

BES sodium salt

GB9133-25G 25 g
EUR 103.2

MES sodium salt

GB1926-10 10
EUR 19.8

MES sodium salt

GB1926-100 100
EUR 79.1

MES sodium salt

GB1926-25 25
EUR 31.7

MES sodium salt

GB1926-250 250
EUR 150.4

MES sodium salt

GB1926-500 500
EUR 265.8

TES sodium salt

GB4016-100 100
EUR 118.7

TES sodium salt

GB4016-25 25
EUR 39.4

TES sodium salt

GB4016-250 250
EUR 237.2

TES sodium salt

GB4016-500 500
EUR 395.5

BES sodium salt

GB9133-100 100
EUR 150.4

BES sodium salt

GB9133-25 25
EUR 55.4

BES sodium salt

GB9133-250 250
EUR 308.5

XTT sodium salt

GC5281-100 100
EUR 174

XTT sodium salt

GC5281-25 25
EUR 63.3

XTT sodium salt

GC5281-250 250
EUR 292.5

XTT sodium salt

GC5281-50 50
EUR 110.7

MOPS SODIUM SALT

213004 each Ask for price

NADP, sodium salt

2737-100 each
EUR 183.6

NADP, sodium salt

2737-1000 each
EUR 940.8

NADP, sodium salt

2737-500 each
EUR 548.4

CHPG Sodium salt

B7475-10 10 mg
EUR 303.6

CHPG Sodium salt

B7475-50 50 mg
EUR 1082.4

CAPS, sodium salt

CB0097 50g
EUR 86.1

MOPS, sodium salt

MDB360S 100g
EUR 106.98

TAPS sodium salt

GB0912-100G 100 g
EUR 160.8

TAPS sodium salt

GB0912-25G 25 g
EUR 74.4

TAPS sodium salt

GB0912-500G 500 g
EUR 409.2

MOPS sodium salt

GB8397-100G 100 g
EUR 79.2

MOPS sodium salt

GB8397-1KG 1 kg
EUR 308.4

MOPS sodium salt

GB8397-250G 250 g
EUR 124.8

MOPS sodium salt

GB8397-25G 25 g
EUR 58.8

MOPS sodium salt

GB8397-500G 500 g
EUR 193.2

DIDS sodium salt

HY-D0086 50mg
EUR 170.4

NADP (sodium salt)

HY-F0002 500mg
EUR 325.2

TAPS, sodium salt

TB0920 50g
EUR 86.1

PNPP sodium salt

GX9577-25 25
EUR 151.6

PNPP sodium salt

GX9577-5 5
EUR 46.6

TAPS sodium salt

GB0912-100 100
EUR 102.7

TAPS sodium salt

GB0912-25 25
EUR 31.7

TAPS sodium salt

GB0912-500 500
EUR 308.5

MOPS sodium salt

GB8397-1 1
EUR 225.3

MOPS sodium salt

GB8397-100 100
EUR 35.5

MOPS sodium salt

GB8397-25 25
EUR 19

MOPS sodium salt

GB8397-250 250
EUR 73.5

MOPS sodium salt

GB8397-500 500
EUR 129.7

D-Glucuronic acid sodium salt monohydrate

GC8431-100G 100 g
EUR 151.2

D-Glucuronic acid sodium salt monohydrate

GC8431-250G 250 g
EUR 274.8

D-Glucuronic acid sodium salt monohydrate

GC8431-25G 25 g
EUR 84

D-Glucuronic acid sodium salt monohydrate

GC8431-5G 5 g
EUR 55.2

D-Glucuronic acid, sodium salt, monohydrate

GB0483 5g
EUR 128.9

D-Glucuronic acid sodium salt monohydrate

GC8431-100 100
EUR 95

D-Glucuronic acid sodium salt monohydrate

GC8431-25 25
EUR 39.4

D-Glucuronic acid sodium salt monohydrate

GC8431-250 250
EUR 197.7

D-Glucuronic acid sodium salt monohydrate

GC8431-5 5
EUR 15.9

HEPES SODIUM SALT

208002 each Ask for price

Hepes, Sodium Salt

CH039 25 g
EUR 141.6

Hepes, Sodium Salt

CH040 100 g
EUR 202.8

Hepes, Sodium Salt

CH041 500 g
EUR 448.8

HEPES Sodium salt

B7303-250000 250 g
EUR 343.2

PIPES Sodium Salt

20-abx082438
  • EUR 326.40
  • EUR 226.80
  • 250 g
  • 25 g

CAPSO, sodium salt

CD0041 50g
EUR 91.32

PIPES, sodium salt

PDB0434 100g
EUR 105.94

MOPSO, sodium salt

MDB0095 25g
EUR 76.7

TAPSO sodium salt

GB1759-100G 100 g
EUR 160.8

TAPSO sodium salt

GB1759-25G 25 g
EUR 74.4

MOPSO sodium salt

GB3228-100G 100 g
EUR 112.8

MOPSO sodium salt

GB3228-250G 250 g
EUR 180

MOPSO sodium salt

GB3228-25G 25 g
EUR 69.6

MOPSO sodium salt

GB3228-500G 500 g
EUR 274.8

CAPSO sodium salt

GB4515-100G 100 g
EUR 132

CAPSO sodium salt

GB4515-250G 250 g
EUR 246

CAPSO sodium salt

GB4515-25G 25 g
EUR 64.8

CAPSO sodium salt

GB4515-500G 500 g
EUR 370.8

DIPSO sodium salt

GB8985-100G 100 g
EUR 394.8

DIPSO sodium salt

GB8985-250G 250 g
EUR 753.6

DIPSO sodium salt

GB8985-25G 25 g
EUR 180

HEPES sodium salt

GB9181-100G 100 g
EUR 84

HEPES sodium salt

GB9181-1KG 1 kg
EUR 274.8

HEPES sodium salt

GB9181-250G 250 g
EUR 118.8

HEPES sodium salt

GB9181-25G 25 g
EUR 64.8

HEPES sodium salt

GB9181-500G 500 g
EUR 180

GJ103 (sodium salt)

HY-101203A 10mM/1mL
EUR 170.4

HEPES, sodium salt

HB0265 50g
EUR 78.79

TAPSO, sodium salt

TB0922 50g
EUR 122.64

TAPSO sodium salt

GB1759-100 100
EUR 102.7

TAPSO sodium salt

GB1759-25 25
EUR 31.7

MOPSO sodium salt

GB3228-100 100
EUR 63.3

MOPSO sodium salt

GB3228-25 25
EUR 27.8

MOPSO sodium salt

GB3228-250 250
EUR 118.7

MOPSO sodium salt

GB3228-500 500
EUR 197.7

CAPSO sodium salt

GB4515-100 100
EUR 79.1

CAPSO sodium salt

GB4515-25 25
EUR 23.8

CAPSO sodium salt

GB4515-250 250
EUR 174

CAPSO sodium salt

GB4515-500 500
EUR 276.9

DIPSO sodium salt

GB8985-100 100
EUR 296.6

DIPSO sodium salt

GB8985-25 25
EUR 118.7

DIPSO sodium salt

GB8985-250 250
EUR 593.3

HEPES sodium salt

GB9181-1 1
EUR 197.7
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