Left ventricular (LV) dysfunction c-kit-positive, lineage-negative cardiac stem cells (CSC) improving post-infarction when given to animals. We conducted an experiment phase 1 (Stem Cell Infusion in Patients with ischemic cardiomyopathy [Scipio]) from autologous CSC for the treatment of heart failure due to ischemic heart disease.In trial stage A Scipio, patients with post-infarction LV dysfunction (ejection fraction [EF] ≤ 40%) prior to coronary artery bypass grafting were consecutively enrolled in the treatment and control groups. In stage B, patients were randomly assigned to treatment or control groups in a ratio of 2: 3 by using the block scheme of computer-generated randomization. 1 million autologous CSC given by intracoronary infusion at an average of 113 days (SE 4) after surgery; untreated controls.
Although this study is an open label, echocardiographic analysis did not know the duties of the group. The primary endpoint was a short-term security of CSC and the secondary endpoint was efficacy. A per-protocol analysis were used. This study is registered with ClinicalTrials.gov, number NCT00474461.This study is still in progress. 16 patients were assigned to the treatment group and seven for the control group; no side effects were reported related CSC.
On 14 CSC-treated patients were analyzed, LVEF increased from 30 · 3% (SE 1 · 9) before CSC infusion to 38 · 5% (2 · 8) at 4 months after infusion (p = 0 · 001). In contrast, the seven control patients, as long as the appropriate time interval, LVEF did not change (30 · 1% [2 · 4] at 4 months after CABG vs 30 · 2% [2 · 5] at 8 months after CABG). Importantly, CSC healthful effects are even more pronounced in the first year in eight patients (eg, LVEF increased by 12 · 3 unit ejection fraction [2 · 1] vs baseline, p = 0 · 0007).
In seven patients treated in whom cardiac MRI can be done, infarct size decreased from 32 · 6 g (6 · 3) by 7 · 8 g (1 · 7; 24%) at 4 months (p = 0 · 004) and 9 · 8 g (3 · 5; 30%) at 1 year (p = 0 · 04) .This preliminary results in patients with very encouraging. They suggest that intracoronary infusion of autologous CSC effective in improving LV systolic function and reduced infarct size in patients with heart failure after myocardial infarction, and warrant further, larger, phase 2 studies.University of Louisville Research Foundation and the National Institutes of Health ,
D-Luciferin sodium salt |
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| B8311-10 | ApexBio | 10 mg | EUR 131 |
D-Luciferin sodium salt |
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| B8311-200 | ApexBio | 200 mg | EUR 699 |
D-Luciferin sodium salt |
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| B8311-50 | ApexBio | 50 mg | EUR 293 |
D-Luciferin, Sodium Salt |
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| 7902-100 | Biovision | EUR 120 | |
D-Luciferin, Sodium Salt |
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| 7902-10G | Biovision | EUR 2409 | |
D-Luciferin, Sodium Salt |
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| 7902-10PK | Biovision | EUR 2763 | |
D-Luciferin, Sodium Salt |
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| 7902-1G | Biovision | EUR 354 | |
D-Luciferin, Sodium Salt |
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| 7902-25G | Biovision | Ask for price | |
D-Luciferin, Sodium Salt |
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| 7902-3PK | Biovision | EUR 925 | |
D-Luciferin, Sodium Salt |
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| 7902-50G | Biovision | Ask for price | |
D-Luciferin, Sodium Salt |
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| 7902-5PK | Biovision | EUR 1496 | |
D-Luciferin potassium salt |
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| HY-12591B | MedChemExpress | 50mg | EUR 153 |
D-Luciferin, Potassium Salt |
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| D0510-010 | GenDepot | 100mg | EUR 185 |
D-Luciferin, Potassium Salt |
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| D0510-050 | GenDepot | 500mg | EUR 504 |
D-Luciferin, Potassium Salt |
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| D0510-100 | GenDepot | 1g | EUR 847 |
D-Luciferin, potassium salt |
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| 10101 | Biotium | 10MG | EUR 112 |
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Description: Minimum order quantity: 1 unit of 10MG |
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D-Luciferin, potassium salt |
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| 10101-1 | Biotium | 50MG | EUR 234 |
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Description: Minimum order quantity: 1 unit of 50MG |
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D-Luciferin, potassium salt |
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| 10101-2 | Biotium | 1G | EUR 714 |
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Description: Minimum order quantity: 1 unit of 1G |
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D-Luciferin, Potassium Salt |
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| 7903-100 | Biovision | EUR 120 | |
D-Luciferin, Potassium Salt |
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| 7903-10G | Biovision | EUR 2409 | |
D-Luciferin, Potassium Salt |
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| 7903-10PK | Biovision | EUR 2763 | |
D-Luciferin, Potassium Salt |
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| 7903-1G | Biovision | EUR 354 | |
D-Luciferin, Potassium Salt |
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| 7903-25G | Biovision | Ask for price | |
D-Luciferin, Potassium Salt |
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| 7903-3PK | Biovision | EUR 925 | |
D-Luciferin, Potassium Salt |
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| 7903-50G | Biovision | Ask for price | |
D-Luciferin, Potassium Salt |
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| 7903-5PK | Biovision | EUR 1496 | |
D-Luciferin, sodium salt *CAS#: 103404-75-7* |
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| 12509 | AAT Bioquest | 25 mg | EUR 115 |
D-Luciferin, sodium salt *CAS#: 103404-75-7* |
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| 12510 | AAT Bioquest | 100 mg | EUR 132 |
D-Luciferin, sodium salt *CAS#: 103404-75-7* |
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| 12511 | AAT Bioquest | 1 g | EUR 528 |
EZSolution? D-Luciferin, Potassium Salt |
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| B3001-set | Biovision | EUR 370 | |
Brite-Light? D-Luciferin, Potassium Salt |
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| B3000-10PK | Biovision | EUR 2268 | |
Brite-Light? D-Luciferin, Potassium Salt |
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| B3000-1G | Biovision | EUR 327 | |
Brite-Light? D-Luciferin, Potassium Salt |
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| B3000-5PK | Biovision | EUR 1300 | |
D-Luciferin |
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| HY-12591A | MedChemExpress | 10mg | EUR 108 |
D-Luciferin |
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| GP9319-100MG | Glentham Life Sciences | 100 mg | EUR 221 |
D-Luciferin |
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| GP9319-10MG | Glentham Life Sciences | 10 mg | EUR 70 |
D-Luciferin |
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| GP9319-25MG | Glentham Life Sciences | 25 mg | EUR 110 |
D-Luciferin |
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| GP9319-50MG | Glentham Life Sciences | 50 mg | EUR 150 |
D-Luciferin |
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| B6040-10 | ApexBio | 10 mg | EUR 131 |
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Description: D-luciferin is a cell-permeable chemiluminescent luciferase substrate with a Km of approximately 2 ?M. D-luciferin could emit lights upon oxidative decarboxylation in the presence of ATP. |
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D-Luciferin |
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| B6040-200 | ApexBio | 200 mg | EUR 699 |
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Description: D-luciferin is a cell-permeable chemiluminescent luciferase substrate with a Km of approximately 2 ?M. D-luciferin could emit lights upon oxidative decarboxylation in the presence of ATP. |
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D-Luciferin |
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| B6040-50 | ApexBio | 50 mg | EUR 293 |
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Description: D-luciferin is a cell-permeable chemiluminescent luciferase substrate with a Km of approximately 2 ?M. D-luciferin could emit lights upon oxidative decarboxylation in the presence of ATP. |
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D-Luciferin, potassium salt *CAS#: 115144-35-9* |
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| 12505 | AAT Bioquest | 25 mg | EUR 115 |
D-Luciferin, potassium salt *CAS#: 115144-35-9* |
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| 12506 | AAT Bioquest | 100 mg | EUR 132 |
D-Luciferin, potassium salt *CAS#: 115144-35-9* |
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| 12507 | AAT Bioquest | 1 g | EUR 263 |
D-Luciferin acetate |
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| 12516 | AAT Bioquest | 5 mg | EUR 219 |
D-Glucuronic acid, sodium salt, monohydrate |
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| GB0483 | Bio Basic | 5g | EUR 107.42 |
Methyl beta-D-glucuronide sodium salt |
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| GC4190-1G | Glentham Life Sciences | 1 g | EUR 229 |
Methyl beta-D-glucuronide sodium salt |
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| GC4190-250MG | Glentham Life Sciences | 250 mg | EUR 110 |
D-Glucuronic acid sodium salt monohydrate |
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| GC8431-100G | Glentham Life Sciences | 100 g | EUR 126 |
D-Glucuronic acid sodium salt monohydrate |
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| GC8431-250G | Glentham Life Sciences | 250 g | EUR 229 |
D-Glucuronic acid sodium salt monohydrate |
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| GC8431-25G | Glentham Life Sciences | 25 g | EUR 70 |
D-Glucuronic acid sodium salt monohydrate |
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| GC8431-5G | Glentham Life Sciences | 5 g | EUR 46 |
D-Glucosamine 2-sulfate sodium salt |
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| GC9126-25MG | Glentham Life Sciences | 25 mg | EUR 61 |
Estradiol 17-(?-D-Glucuronide) (sodium salt) |
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| C3840-5 | ApexBio | 5 mg | EUR 132 |
|
Description: Km: 75 ?MEstradiol 17-(?-D-Glucuronide) is a substrate of the multidrug resistance protein 2 (MRP2).MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes. |
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Estradiol 17-(?-D-Glucuronide) (sodium salt) |
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| C3840-10 | ApexBio | 10 mg | EUR 206 |
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Description: Km: 75 ?MEstradiol 17-(?-D-Glucuronide) is a substrate of the multidrug resistance protein 2 (MRP2).MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes. |
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Estradiol 17-(?-D-Glucuronide) (sodium salt) |
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| C3840-25 | ApexBio | 25 mg | EUR 338 |
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Description: Km: 75 ?MEstradiol 17-(?-D-Glucuronide) is a substrate of the multidrug resistance protein 2 (MRP2).MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes. |
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Estradiol 17-(?-D-Glucuronide) (sodium salt) |
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| C3840-50 | ApexBio | 50 mg | EUR 502 |
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Description: Km: 75 ?MEstradiol 17-(?-D-Glucuronide) is a substrate of the multidrug resistance protein 2 (MRP2).MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes. |
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Estradiol 3-(?-D-Glucuronide) (sodium salt) |
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| C3897-1 | ApexBio | 1 mg | EUR 118 |
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Description: ?-estradiol 3-(?-d-glucuronide) (E23G) is a noncholestatic regioisomer of the estrogen metabolite, E217G (?-Estradiol 17-(?-d-glucuronide)) [1]. E23G functions as a substrate for multidrug resistance associated protein 2 (MRP2) [2]. |
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Estradiol 3-(?-D-Glucuronide) (sodium salt) |
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| C3897-10 | ApexBio | 10 mg | EUR 527 |
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Description: ?-estradiol 3-(?-d-glucuronide) (E23G) is a noncholestatic regioisomer of the estrogen metabolite, E217G (?-Estradiol 17-(?-d-glucuronide)) [1]. E23G functions as a substrate for multidrug resistance associated protein 2 (MRP2) [2]. |
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Estradiol 3-(?-D-Glucuronide) (sodium salt) |
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| C3897-25 | ApexBio | 25 mg | EUR 1073 |
|
Description: ?-estradiol 3-(?-d-glucuronide) (E23G) is a noncholestatic regioisomer of the estrogen metabolite, E217G (?-Estradiol 17-(?-d-glucuronide)) [1]. E23G functions as a substrate for multidrug resistance associated protein 2 (MRP2) [2]. |
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Estradiol 3-(?-D-Glucuronide) (sodium salt) |
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| C3897-5 | ApexBio | 5 mg | EUR 306 |
|
Description: ?-estradiol 3-(?-d-glucuronide) (E23G) is a noncholestatic regioisomer of the estrogen metabolite, E217G (?-Estradiol 17-(?-d-glucuronide)) [1]. E23G functions as a substrate for multidrug resistance associated protein 2 (MRP2) [2]. |
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D-Luciferin, free acid |
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| 10100 | Biotium | 10MG | EUR 112 |
|
Description: Minimum order quantity: 1 unit of 10MG |
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D-Luciferin, free acid |
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| 10100-1 | Biotium | 50MG | EUR 234 |
|
Description: Minimum order quantity: 1 unit of 50MG |
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D-Luciferin, free acid |
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| 10100-2 | Biotium | 1G | EUR 714 |
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Description: Minimum order quantity: 1 unit of 1G |
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D-Luciferin (Free acid) |
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| 2779-1000 | Biovision | EUR 338 | |
D-Luciferin (Free acid) |
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| 2779-250 | Biovision | EUR 175 | |
D-Luciferin (Free acid) |
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| 2779-500 | Biovision | EUR 251 | |
D-Luciferin (Free acid) |
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| 2779-5000 | Biovision | EUR 1273 | |
Cromolyn sodium salt |
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| SB0843 | Bio Basic | 5g | EUR 65.66 |
Methotrexate sodium salt |
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| M031-250MG | TOKU-E | 250 mg | EUR 117 |
Monensin Sodium Salt |
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| M083-1G | TOKU-E | 1 g | EUR 71 |
Monensin Sodium Salt |
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| M083-5x1G | TOKU-E | 5 x 1 g | EUR 159 |
MES, sodium salt |
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| MB0611 | Bio Basic | 50g | EUR 74.36 |
MOPSO, sodium salt |
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| MDB0095 | Bio Basic | 25g | EUR 63.92 |
MOPS, sodium salt |
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| MDB360S | Bio Basic | 100g | EUR 89.15 |
Entacapone (sodium salt) |
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| HY-14280A | MedChemExpress | 10mg | EUR 119 |
Grazoprevir sodium salt |
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| HY-15298C | MedChemExpress | 10mg | EUR 243 |
Luminol (sodium salt) |
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| HY-15922A | MedChemExpress | 500mg | EUR 108 |
Salinomycin (sodium salt) |
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| HY-17439 | MedChemExpress | 100mg | EUR 187 |
Heparin (sodium salt) |
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| HY-17567A | MedChemExpress | 500mg | EUR 147 |
Seladelpar sodium salt |
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| HY-19522A | MedChemExpress | 10mM/1mL | EUR 163 |
Etomoxir (sodium salt) |
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| HY-50202A | MedChemExpress | 5mg | EUR 147 |
Silmitasertib (sodium salt) |
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| HY-50855B | MedChemExpress | 10mg | EUR 187 |
Cefotaxime (sodium salt) |
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| HY-A0088 | MedChemExpress | 10mM/1mL | EUR 113 |
Adapalene (sodium salt) |
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| HY-B0091A | MedChemExpress | 500mg | EUR 326 |
Cefoperazone (sodium salt) |
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| HY-B0210A | MedChemExpress | 500mg | EUR 108 |
Sulfamerazine (sodium salt) |
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| HY-B0512A | MedChemExpress | 500mg | EUR 131 |
Azlocillin (sodium salt) |
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| HY-B0529A | MedChemExpress | 500mg | EUR 113 |
Ceftriaxone (sodium salt) |
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| HY-B0712B | MedChemExpress | 500mg | EUR 173 |
Citicoline sodium salt |
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| HY-B0739A | MedChemExpress | 100mg | EUR 108 |
Bucladesine (sodium salt) |
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| HY-B0764 | MedChemExpress | 50mg | EUR 139 |
Cloprostenol sodium salt |
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| HY-108415 | MedChemExpress | 10mg | EUR 349 |
Fosmidomycin sodium salt |
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| HY-112853 | MedChemExpress | 5mg | EUR 349 |
Zidebactam sodium salt |
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| HY-120859A | MedChemExpress | 10mg | EUR 1025 |
Resorufin sodium salt |
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| HY-123533A | MedChemExpress | 100mg | EUR 142 |
Batimastat (sodium salt) |
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| HY-13564A | MedChemExpress | 5mg | EUR 187 |
HEPES, sodium salt |
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| HB0265 | Bio Basic | 50g | EUR 65.66 |
HEPPSO, sodium salt |
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| HB0496 | Bio Basic | 25g | EUR 97.85 |
Nigericin (sodium salt) |
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| HY-100381 | MedChemExpress | 100mg | EUR 725 |
Setogepram (sodium salt) |
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| HY-100775 | MedChemExpress | 10mM/1mL | EUR 327 |
GJ103 (sodium salt) |
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| HY-101203A | MedChemExpress | 10mM/1mL | EUR 142 |
Moniliformin (sodium salt) |
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| HY-101905 | MedChemExpress | 1mg | EUR 312 |
Danshensu (sodium salt) |
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| HY-N0106 | MedChemExpress | 200mg | EUR 291 |
Monensin sodium salt |
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| HY-N0150 | MedChemExpress | 100mg | EUR 108 |
XTT, sodium salt |
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| PB2525 | Bio Basic | 250mg | EUR 269.24 |
PIPES, sodium salt |
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| PDB0434 | Bio Basic | 100g | EUR 88.28 |
Suramin (sodium salt) |
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| HY-B0879A | MedChemExpress | 50mg | EUR 394 |
Zomepirac (sodium salt) |
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| HY-B0890 | MedChemExpress | 500mg | EUR 160 |
Oxacillin (sodium salt) |
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| HY-B0925 | MedChemExpress | 100mg | EUR 119 |
Methicillin (sodium salt) |
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| HY-B0974 | MedChemExpress | 10mM/1mL | EUR 126 |
Sulfaquinoxaline sodium salt |
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| HY-B1282A | MedChemExpress | 100mg | EUR 119 |
Lorglumide sodium salt |
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| HY-B1439B | MedChemExpress | 5mg | EUR 119 |
Moxalactam (sodium salt) |
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| HY-B1484 | MedChemExpress | 200mg | EUR 147 |
DIDS sodium salt |
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| HY-D0086 | MedChemExpress | 50mg | EUR 142 |
NADP (sodium salt) |
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| HY-F0002 | MedChemExpress | 500mg | EUR 271 |
TAPS, sodium salt |
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| TB0920 | Bio Basic | 50g | EUR 71.75 |
TAPSO, sodium salt |
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| TB0922 | Bio Basic | 50g | EUR 102.2 |
MES sodium salt |
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| GB1926-10G | Glentham Life Sciences | 10 g | EUR 50 |
MES sodium salt |
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| GB1926-250G | Glentham Life Sciences | 250 g | EUR 181 |
MES sodium salt |
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| GB1926-500G | Glentham Life Sciences | 500 g | EUR 298 |
MOPSO sodium salt |
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| GB3228-100G | Glentham Life Sciences | 100 g | EUR 94 |
MOPSO sodium salt |
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| GB3228-25G | Glentham Life Sciences | 25 g | EUR 58 |
MOPSO sodium salt |
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| GB3228-500G | Glentham Life Sciences | 500 g | EUR 229 |
TES sodium salt |
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| GB4016-100G | Glentham Life Sciences | 100 g | EUR 150 |
TES sodium salt |
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| GB4016-500G | Glentham Life Sciences | 500 g | EUR 429 |
CAPSO sodium salt |
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| GB4515-100G | Glentham Life Sciences | 100 g | EUR 110 |
CAPSO sodium salt |
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| GB4515-25G | Glentham Life Sciences | 25 g | EUR 54 |
CAPSO sodium salt |
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| GB4515-500G | Glentham Life Sciences | 500 g | EUR 309 |
MOPS sodium salt |
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| GB8397-100G | Glentham Life Sciences | 100 g | EUR 66 |
MOPS sodium salt |
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| GB8397-1KG | Glentham Life Sciences | 1 kg | EUR 257 |
DIPSO sodium salt |
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| GB8985-250G | Glentham Life Sciences | 250 g | EUR 628 |
BES sodium salt |
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| GB9133-25G | Glentham Life Sciences | 25 g | EUR 86 |
HEPES sodium salt |
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| GB9181-250G | Glentham Life Sciences | 250 g | EUR 99 |
HEPES sodium salt |
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| GB9181-500G | Glentham Life Sciences | 500 g | EUR 150 |
Heparin sodium salt |
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| GC2310-100MG | Glentham Life Sciences | 100 mg | EUR 46 |
Heparin sodium salt |
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| GC2310-1G | Glentham Life Sciences | 1 g | EUR 82 |
Heparin sodium salt |
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| GC2310-250MG | Glentham Life Sciences | 250 mg | EUR 54 |
XTT sodium salt |
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| GC5281-100MG | Glentham Life Sciences | 100 mg | EUR 205 |
XTT sodium salt |
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| GC5281-250MG | Glentham Life Sciences | 250 mg | EUR 325 |
XTT sodium salt |
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| GC5281-25MG | Glentham Life Sciences | 25 mg | EUR 94 |
XTT sodium salt |
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| GC5281-50MG | Glentham Life Sciences | 50 mg | EUR 142 |
Casein sodium salt |
|||
| GE5861-100G | Glentham Life Sciences | 100 g | EUR 43 |
Casein sodium salt |
|||
| GE5861-1KG | Glentham Life Sciences | 1 kg | EUR 70 |
Casein sodium salt |
|||
| GE5861-250G | Glentham Life Sciences | 250 g | EUR 47 |
Casein sodium salt |
|||
| GE5861-500G | Glentham Life Sciences | 500 g | EUR 54 |
TAPS sodium salt |
|||
| GB0912-100G | Glentham Life Sciences | 100 g | EUR 134 |
TAPS sodium salt |
|||
| GB0912-25G | Glentham Life Sciences | 25 g | EUR 62 |
TAPS sodium salt |
|||
| GB0912-500G | Glentham Life Sciences | 500 g | EUR 341 |
TAPSO sodium salt |
|||
| GB1759-100G | Glentham Life Sciences | 100 g | EUR 134 |
TAPSO sodium salt |
|||
| GB1759-25G | Glentham Life Sciences | 25 g | EUR 62 |
MES sodium salt |
|||
| GB1926-100G | Glentham Life Sciences | 100 g | EUR 110 |
MES sodium salt |
|||
| GB1926-25G | Glentham Life Sciences | 25 g | EUR 62 |
MOPSO sodium salt |
|||
| GB3228-250G | Glentham Life Sciences | 250 g | EUR 150 |
TES sodium salt |
|||
| GB4016-250G | Glentham Life Sciences | 250 g | EUR 269 |
TES sodium salt |
|||
| GB4016-25G | Glentham Life Sciences | 25 g | EUR 70 |