Left ventricular (LV) dysfunction c-kit-positive, lineage-negative cardiac stem cells (CSC) improving post-infarction when given to animals. We conducted an experiment phase 1 (Stem Cell Infusion in Patients with ischemic cardiomyopathy [Scipio]) from autologous CSC for the treatment of heart failure due to ischemic heart disease.In trial stage A Scipio, patients with post-infarction LV dysfunction (ejection fraction [EF] ≤ 40%) prior to coronary artery bypass grafting were consecutively enrolled in the treatment and control groups. In stage B, patients were randomly assigned to treatment or control groups in a ratio of 2: 3 by using the block scheme of computer-generated randomization. 1 million autologous CSC given by intracoronary infusion at an average of 113 days (SE 4) after surgery; untreated controls.
Although this study is an open label, echocardiographic analysis did not know the duties of the group. The primary endpoint was a short-term security of CSC and the secondary endpoint was efficacy. A per-protocol analysis were used. This study is registered with ClinicalTrials.gov, number NCT00474461.This study is still in progress. 16 patients were assigned to the treatment group and seven for the control group; no side effects were reported related CSC.
On 14 CSC-treated patients were analyzed, LVEF increased from 30 · 3% (SE 1 · 9) before CSC infusion to 38 · 5% (2 · 8) at 4 months after infusion (p = 0 · 001). In contrast, the seven control patients, as long as the appropriate time interval, LVEF did not change (30 · 1% [2 · 4] at 4 months after CABG vs 30 · 2% [2 · 5] at 8 months after CABG). Importantly, CSC healthful effects are even more pronounced in the first year in eight patients (eg, LVEF increased by 12 · 3 unit ejection fraction [2 · 1] vs baseline, p = 0 · 0007).
In seven patients treated in whom cardiac MRI can be done, infarct size decreased from 32 · 6 g (6 · 3) by 7 · 8 g (1 · 7; 24%) at 4 months (p = 0 · 004) and 9 · 8 g (3 · 5; 30%) at 1 year (p = 0 · 04) .This preliminary results in patients with very encouraging. They suggest that intracoronary infusion of autologous CSC effective in improving LV systolic function and reduced infarct size in patients with heart failure after myocardial infarction, and warrant further, larger, phase 2 studies.University of Louisville Research Foundation and the National Institutes of Health ,
D-Luciferin sodium salt |
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| B8311-200 | ApexBio | 200 mg | EUR 838.8 |
D-Luciferin sodium salt |
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| B8311-50 | ApexBio | 50 mg | EUR 351.6 |
D-Luciferin, Sodium Salt |
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| 7902-100 | Biovision | each | EUR 144 |
D-Luciferin, Sodium Salt |
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| 7902-10G | Biovision | each | EUR 2890.8 |
D-Luciferin, Sodium Salt |
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| 7902-10PK | Biovision | each | EUR 3315.6 |
D-Luciferin, Sodium Salt |
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| 7902-1G | Biovision | each | EUR 424.8 |
D-Luciferin, Sodium Salt |
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| 7902-25G | Biovision | each | Ask for price |
D-Luciferin, Sodium Salt |
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| 7902-3PK | Biovision | each | EUR 1110 |
D-Luciferin, Sodium Salt |
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| 7902-50G | Biovision | each | Ask for price |
D-Luciferin, Sodium Salt |
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| 7902-5PK | Biovision | each | EUR 1795.2 |
D-Luciferin (sodium salt) |
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| HY-12591 | MedChemExpress | 50mg | EUR 183.6 |
D-Luciferin sodium salt |
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| GP8979-100 | Glentham Life Sciences | 100 | EUR 310.6 |
D-Luciferin sodium salt |
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| GP8979-25 | Glentham Life Sciences | 25 | EUR 113.1 |
D-Luciferin, sodium salt *CAS#: 103404-75-7* |
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| 12509 | AAT Bioquest | 25 mg | EUR 86 |
D-Luciferin, sodium salt *CAS#: 103404-75-7* |
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| 12510 | AAT Bioquest | 100 mg | EUR 109 |
D-Luciferin, sodium salt *CAS#: 103404-75-7* |
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| 12511 | AAT Bioquest | 1 g | EUR 621 |
D-Luciferin, sodium salt *CAS#: 103404-75-7* |
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| 12509-25mg | AAT Bioquest | 25 mg | EUR 86 |
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Description: Luciferin is the most popular and versatile bioluminescent substrate. |
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D-Luciferin, sodium salt *CAS#: 103404-75-7* |
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| 12510-100mg | AAT Bioquest | 100 mg | EUR 109 |
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Description: Luciferin is the most popular and versatile bioluminescent substrate. |
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D-Luciferin, sodium salt *CAS#: 103404-75-7* |
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| 12511-1g | AAT Bioquest | 1 g | EUR 621 |
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Description: Luciferin is the most popular and versatile bioluminescent substrate. |
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D-Galacturonic acid sodium salt |
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| GC4898-25 | Glentham Life Sciences | 25 | EUR 318.6 |
D-Galacturonic acid sodium salt |
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| GC4898-250 | Glentham Life Sciences | 250 | EUR 1960.5 |
D-Galacturonic acid sodium salt |
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| GC4898-5 | Glentham Life Sciences | 5 | EUR 135.7 |
D-Mannopyranuronic acid, sodium salt |
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| GC5971-10 | Glentham Life Sciences | 10 | EUR 344.8 |
D-Mannopyranuronic acid, sodium salt |
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| GC5971-100 | Glentham Life Sciences | 100 | EUR 1444.9 |
D-Mannopyranuronic acid, sodium salt |
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| GC5971-25 | Glentham Life Sciences | 25 | EUR 624.6 |
D-Mannopyranuronic acid, sodium salt |
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| GC5971-50 | Glentham Life Sciences | 50 | EUR 932.2 |
D-Glucosamine 2-sulfate sodium salt |
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| GC9126-25MG | Glentham Life Sciences | 25 mg | EUR 73.2 |
D-Glucosamine 2-sulfate sodium salt |
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| GC9126-25 | Glentham Life Sciences | 25 | EUR 30.9 |
Estradiol 17-(?-D-Glucuronide) (sodium salt) |
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| C3840-10 | ApexBio | 10 mg | EUR 247.2 |
|
Description: Km: 75 ?MEstradiol 17-(?-D-Glucuronide) is a substrate of the multidrug resistance protein 2 (MRP2).MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes. |
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Estradiol 17-(?-D-Glucuronide) (sodium salt) |
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| C3840-25 | ApexBio | 25 mg | EUR 405.6 |
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Description: Km: 75 ?MEstradiol 17-(?-D-Glucuronide) is a substrate of the multidrug resistance protein 2 (MRP2).MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes. |
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Estradiol 17-(?-D-Glucuronide) (sodium salt) |
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| C3840-5 | ApexBio | 5 mg | EUR 158.4 |
|
Description: Km: 75 ?MEstradiol 17-(?-D-Glucuronide) is a substrate of the multidrug resistance protein 2 (MRP2).MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes. |
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Estradiol 17-(?-D-Glucuronide) (sodium salt) |
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| C3840-50 | ApexBio | 50 mg | EUR 602.4 |
|
Description: Km: 75 ?MEstradiol 17-(?-D-Glucuronide) is a substrate of the multidrug resistance protein 2 (MRP2).MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes. |
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Estradiol 3-(?-D-Glucuronide) (sodium salt) |
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| C3897-1 | ApexBio | 1 mg | EUR 141.6 |
|
Description: ?-estradiol 3-(?-d-glucuronide) (E23G) is a noncholestatic regioisomer of the estrogen metabolite, E217G (?-Estradiol 17-(?-d-glucuronide)) [1]. E23G functions as a substrate for multidrug resistance associated protein 2 (MRP2) [2]. |
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Estradiol 3-(?-D-Glucuronide) (sodium salt) |
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| C3897-10 | ApexBio | 10 mg | EUR 632.4 |
|
Description: ?-estradiol 3-(?-d-glucuronide) (E23G) is a noncholestatic regioisomer of the estrogen metabolite, E217G (?-Estradiol 17-(?-d-glucuronide)) [1]. E23G functions as a substrate for multidrug resistance associated protein 2 (MRP2) [2]. |
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Estradiol 3-(?-D-Glucuronide) (sodium salt) |
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| C3897-25 | ApexBio | 25 mg | EUR 1287.6 |
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Description: ?-estradiol 3-(?-d-glucuronide) (E23G) is a noncholestatic regioisomer of the estrogen metabolite, E217G (?-Estradiol 17-(?-d-glucuronide)) [1]. E23G functions as a substrate for multidrug resistance associated protein 2 (MRP2) [2]. |
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Estradiol 3-(?-D-Glucuronide) (sodium salt) |
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| C3897-5 | ApexBio | 5 mg | EUR 367.2 |
|
Description: ?-estradiol 3-(?-d-glucuronide) (E23G) is a noncholestatic regioisomer of the estrogen metabolite, E217G (?-Estradiol 17-(?-d-glucuronide)) [1]. E23G functions as a substrate for multidrug resistance associated protein 2 (MRP2) [2]. |
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Methyl beta-D-glucuronide sodium salt |
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| GC4190-1G | Glentham Life Sciences | 1 g | EUR 274.8 |
Methyl beta-D-glucuronide sodium salt |
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| GC4190-250MG | Glentham Life Sciences | 250 mg | EUR 132 |
MES SODIUM SALT |
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| 213002 | Survival Technologies | each | Ask for price |
XTT, sodium salt |
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| PB2525 | Bio Basic | 250mg | EUR 323.09 |
MES, sodium salt |
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| MB0611 | Bio Basic | 50g | EUR 89.23 |
XTT sodium salt |
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| GC5281-100MG | Glentham Life Sciences | 100 mg | EUR 246 |
XTT sodium salt |
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| GC5281-250MG | Glentham Life Sciences | 250 mg | EUR 390 |
XTT sodium salt |
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| GC5281-25MG | Glentham Life Sciences | 25 mg | EUR 112.8 |
XTT sodium salt |
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| GC5281-50MG | Glentham Life Sciences | 50 mg | EUR 170.4 |
MES sodium salt |
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| GB1926-100G | Glentham Life Sciences | 100 g | EUR 132 |
MES sodium salt |
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| GB1926-10G | Glentham Life Sciences | 10 g | EUR 60 |
MES sodium salt |
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| GB1926-250G | Glentham Life Sciences | 250 g | EUR 217.2 |
MES sodium salt |
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| GB1926-25G | Glentham Life Sciences | 25 g | EUR 74.4 |
MES sodium salt |
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| GB1926-500G | Glentham Life Sciences | 500 g | EUR 357.6 |
TES sodium salt |
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| GB4016-100G | Glentham Life Sciences | 100 g | EUR 180 |
TES sodium salt |
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| GB4016-250G | Glentham Life Sciences | 250 g | EUR 322.8 |
TES sodium salt |
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| GB4016-25G | Glentham Life Sciences | 25 g | EUR 84 |
TES sodium salt |
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| GB4016-500G | Glentham Life Sciences | 500 g | EUR 514.8 |
BES sodium salt |
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| GB9133-100G | Glentham Life Sciences | 100 g | EUR 217.2 |
BES sodium salt |
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| GB9133-250G | Glentham Life Sciences | 250 g | EUR 409.2 |
BES sodium salt |
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| GB9133-25G | Glentham Life Sciences | 25 g | EUR 103.2 |
MES sodium salt |
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| GB1926-10 | Glentham Life Sciences | 10 | EUR 19.8 |
MES sodium salt |
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| GB1926-100 | Glentham Life Sciences | 100 | EUR 79.1 |
MES sodium salt |
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| GB1926-25 | Glentham Life Sciences | 25 | EUR 31.7 |
MES sodium salt |
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| GB1926-250 | Glentham Life Sciences | 250 | EUR 150.4 |
MES sodium salt |
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| GB1926-500 | Glentham Life Sciences | 500 | EUR 265.8 |
TES sodium salt |
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| GB4016-100 | Glentham Life Sciences | 100 | EUR 118.7 |
TES sodium salt |
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| GB4016-25 | Glentham Life Sciences | 25 | EUR 39.4 |
TES sodium salt |
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| GB4016-250 | Glentham Life Sciences | 250 | EUR 237.2 |
TES sodium salt |
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| GB4016-500 | Glentham Life Sciences | 500 | EUR 395.5 |
BES sodium salt |
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| GB9133-100 | Glentham Life Sciences | 100 | EUR 150.4 |
BES sodium salt |
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| GB9133-25 | Glentham Life Sciences | 25 | EUR 55.4 |
BES sodium salt |
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| GB9133-250 | Glentham Life Sciences | 250 | EUR 308.5 |
XTT sodium salt |
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| GC5281-100 | Glentham Life Sciences | 100 | EUR 174 |
XTT sodium salt |
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| GC5281-25 | Glentham Life Sciences | 25 | EUR 63.3 |
XTT sodium salt |
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| GC5281-250 | Glentham Life Sciences | 250 | EUR 292.5 |
XTT sodium salt |
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| GC5281-50 | Glentham Life Sciences | 50 | EUR 110.7 |
MOPS SODIUM SALT |
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| 213004 | Survival Technologies | each | Ask for price |
NADP, sodium salt |
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| 2737-100 | Biovision | each | EUR 183.6 |
NADP, sodium salt |
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| 2737-1000 | Biovision | each | EUR 940.8 |
NADP, sodium salt |
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| 2737-500 | Biovision | each | EUR 548.4 |
CHPG Sodium salt |
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| B7475-10 | ApexBio | 10 mg | EUR 303.6 |
CHPG Sodium salt |
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| B7475-50 | ApexBio | 50 mg | EUR 1082.4 |
CAPS, sodium salt |
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| CB0097 | Bio Basic | 50g | EUR 86.1 |
MOPS, sodium salt |
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| MDB360S | Bio Basic | 100g | EUR 106.98 |
TAPS sodium salt |
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| GB0912-100G | Glentham Life Sciences | 100 g | EUR 160.8 |
TAPS sodium salt |
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| GB0912-25G | Glentham Life Sciences | 25 g | EUR 74.4 |
TAPS sodium salt |
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| GB0912-500G | Glentham Life Sciences | 500 g | EUR 409.2 |
MOPS sodium salt |
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| GB8397-100G | Glentham Life Sciences | 100 g | EUR 79.2 |
MOPS sodium salt |
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| GB8397-1KG | Glentham Life Sciences | 1 kg | EUR 308.4 |
MOPS sodium salt |
|||
| GB8397-250G | Glentham Life Sciences | 250 g | EUR 124.8 |
MOPS sodium salt |
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| GB8397-25G | Glentham Life Sciences | 25 g | EUR 58.8 |
MOPS sodium salt |
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| GB8397-500G | Glentham Life Sciences | 500 g | EUR 193.2 |
DIDS sodium salt |
|||
| HY-D0086 | MedChemExpress | 50mg | EUR 170.4 |
NADP (sodium salt) |
|||
| HY-F0002 | MedChemExpress | 500mg | EUR 325.2 |
TAPS, sodium salt |
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| TB0920 | Bio Basic | 50g | EUR 86.1 |
PNPP sodium salt |
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| GX9577-25 | Glentham Life Sciences | 25 | EUR 151.6 |
PNPP sodium salt |
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| GX9577-5 | Glentham Life Sciences | 5 | EUR 46.6 |
TAPS sodium salt |
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| GB0912-100 | Glentham Life Sciences | 100 | EUR 102.7 |
TAPS sodium salt |
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| GB0912-25 | Glentham Life Sciences | 25 | EUR 31.7 |
TAPS sodium salt |
|||
| GB0912-500 | Glentham Life Sciences | 500 | EUR 308.5 |
MOPS sodium salt |
|||
| GB8397-1 | Glentham Life Sciences | 1 | EUR 225.3 |
MOPS sodium salt |
|||
| GB8397-100 | Glentham Life Sciences | 100 | EUR 35.5 |
MOPS sodium salt |
|||
| GB8397-25 | Glentham Life Sciences | 25 | EUR 19 |
MOPS sodium salt |
|||
| GB8397-250 | Glentham Life Sciences | 250 | EUR 73.5 |
MOPS sodium salt |
|||
| GB8397-500 | Glentham Life Sciences | 500 | EUR 129.7 |
D-Glucuronic acid sodium salt monohydrate |
|||
| GC8431-100G | Glentham Life Sciences | 100 g | EUR 151.2 |
D-Glucuronic acid sodium salt monohydrate |
|||
| GC8431-250G | Glentham Life Sciences | 250 g | EUR 274.8 |
D-Glucuronic acid sodium salt monohydrate |
|||
| GC8431-25G | Glentham Life Sciences | 25 g | EUR 84 |
D-Glucuronic acid sodium salt monohydrate |
|||
| GC8431-5G | Glentham Life Sciences | 5 g | EUR 55.2 |
D-Glucuronic acid, sodium salt, monohydrate |
|||
| GB0483 | Bio Basic | 5g | EUR 128.9 |
D-Glucuronic acid sodium salt monohydrate |
|||
| GC8431-100 | Glentham Life Sciences | 100 | EUR 95 |
D-Glucuronic acid sodium salt monohydrate |
|||
| GC8431-25 | Glentham Life Sciences | 25 | EUR 39.4 |
D-Glucuronic acid sodium salt monohydrate |
|||
| GC8431-250 | Glentham Life Sciences | 250 | EUR 197.7 |
D-Glucuronic acid sodium salt monohydrate |
|||
| GC8431-5 | Glentham Life Sciences | 5 | EUR 15.9 |
HEPES SODIUM SALT |
|||
| 208002 | Survival Technologies | each | Ask for price |
Hepes, Sodium Salt |
|||
| CH039 | ABM | 25 g | EUR 141.6 |
Hepes, Sodium Salt |
|||
| CH040 | ABM | 100 g | EUR 202.8 |
Hepes, Sodium Salt |
|||
| CH041 | ABM | 500 g | EUR 448.8 |
HEPES Sodium salt |
|||
| B7303-250000 | ApexBio | 250 g | EUR 343.2 |
PIPES Sodium Salt |
|||
| 20-abx082438 | Abbexa |
|
|
CAPSO, sodium salt |
|||
| CD0041 | Bio Basic | 50g | EUR 91.32 |
PIPES, sodium salt |
|||
| PDB0434 | Bio Basic | 100g | EUR 105.94 |
MOPSO, sodium salt |
|||
| MDB0095 | Bio Basic | 25g | EUR 76.7 |
TAPSO sodium salt |
|||
| GB1759-100G | Glentham Life Sciences | 100 g | EUR 160.8 |
TAPSO sodium salt |
|||
| GB1759-25G | Glentham Life Sciences | 25 g | EUR 74.4 |
MOPSO sodium salt |
|||
| GB3228-100G | Glentham Life Sciences | 100 g | EUR 112.8 |
MOPSO sodium salt |
|||
| GB3228-250G | Glentham Life Sciences | 250 g | EUR 180 |
MOPSO sodium salt |
|||
| GB3228-25G | Glentham Life Sciences | 25 g | EUR 69.6 |
MOPSO sodium salt |
|||
| GB3228-500G | Glentham Life Sciences | 500 g | EUR 274.8 |
CAPSO sodium salt |
|||
| GB4515-100G | Glentham Life Sciences | 100 g | EUR 132 |
CAPSO sodium salt |
|||
| GB4515-250G | Glentham Life Sciences | 250 g | EUR 246 |
CAPSO sodium salt |
|||
| GB4515-25G | Glentham Life Sciences | 25 g | EUR 64.8 |
CAPSO sodium salt |
|||
| GB4515-500G | Glentham Life Sciences | 500 g | EUR 370.8 |
DIPSO sodium salt |
|||
| GB8985-100G | Glentham Life Sciences | 100 g | EUR 394.8 |
DIPSO sodium salt |
|||
| GB8985-250G | Glentham Life Sciences | 250 g | EUR 753.6 |
DIPSO sodium salt |
|||
| GB8985-25G | Glentham Life Sciences | 25 g | EUR 180 |
HEPES sodium salt |
|||
| GB9181-100G | Glentham Life Sciences | 100 g | EUR 84 |
HEPES sodium salt |
|||
| GB9181-1KG | Glentham Life Sciences | 1 kg | EUR 274.8 |
HEPES sodium salt |
|||
| GB9181-250G | Glentham Life Sciences | 250 g | EUR 118.8 |
HEPES sodium salt |
|||
| GB9181-25G | Glentham Life Sciences | 25 g | EUR 64.8 |
HEPES sodium salt |
|||
| GB9181-500G | Glentham Life Sciences | 500 g | EUR 180 |
GJ103 (sodium salt) |
|||
| HY-101203A | MedChemExpress | 10mM/1mL | EUR 170.4 |
HEPES, sodium salt |
|||
| HB0265 | Bio Basic | 50g | EUR 78.79 |
TAPSO, sodium salt |
|||
| TB0922 | Bio Basic | 50g | EUR 122.64 |
TAPSO sodium salt |
|||
| GB1759-100 | Glentham Life Sciences | 100 | EUR 102.7 |
TAPSO sodium salt |
|||
| GB1759-25 | Glentham Life Sciences | 25 | EUR 31.7 |
MOPSO sodium salt |
|||
| GB3228-100 | Glentham Life Sciences | 100 | EUR 63.3 |
MOPSO sodium salt |
|||
| GB3228-25 | Glentham Life Sciences | 25 | EUR 27.8 |
MOPSO sodium salt |
|||
| GB3228-250 | Glentham Life Sciences | 250 | EUR 118.7 |
MOPSO sodium salt |
|||
| GB3228-500 | Glentham Life Sciences | 500 | EUR 197.7 |
CAPSO sodium salt |
|||
| GB4515-100 | Glentham Life Sciences | 100 | EUR 79.1 |
CAPSO sodium salt |
|||
| GB4515-25 | Glentham Life Sciences | 25 | EUR 23.8 |
CAPSO sodium salt |
|||
| GB4515-250 | Glentham Life Sciences | 250 | EUR 174 |
CAPSO sodium salt |
|||
| GB4515-500 | Glentham Life Sciences | 500 | EUR 276.9 |
DIPSO sodium salt |
|||
| GB8985-100 | Glentham Life Sciences | 100 | EUR 296.6 |
DIPSO sodium salt |
|||
| GB8985-25 | Glentham Life Sciences | 25 | EUR 118.7 |
DIPSO sodium salt |
|||
| GB8985-250 | Glentham Life Sciences | 250 | EUR 593.3 |
HEPES sodium salt |
|||
| GB9181-1 | Glentham Life Sciences | 1 | EUR 197.7 |